Behavioral and biochemical evidence of apomorphine-induced supersensitivity of the striatal dopamine receptors - PubMed (original) (raw)
Behavioral and biochemical evidence of apomorphine-induced supersensitivity of the striatal dopamine receptors
P Deshaies et al. Neuropharmacology. 1984 Oct.
Abstract
The effect of repeated administration of apomorphine was studied behaviorally and biochemically in rats bearing either a unilateral lesion of the substantia nigra with 6-OHDA or an electrolytic lesion of the entopeduncular nucleus. Rats with the nigral lesion displayed a progressive increase in contralateral circling rate. In animals with the entopeduncular lesion, the ipsiversive circling response was unchanged after the eight injection of apomorphine. [3H] Spiroperidol binding to striatal membranes did not appear modified by the apomorphine treatment on the intact side. It was however increased on the side of the 6-OHDA lesion. We propose that a denervated striatum responds to repeated stimulation by dopamine agonists with a paradoxical increase in sensitivity. This may explain in part the appearance of dyskinesia in treated parkinsonian patients.
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