Thermal dose determination in cancer therapy - PubMed (original) (raw)
Thermal dose determination in cancer therapy
S A Sapareto et al. Int J Radiat Oncol Biol Phys. 1984 Jun.
Abstract
With the rapid development of clinical hyperthermia for the treatment of cancer either alone or in conjunction with other modalities, a means of measuring a thermal dose in terms which are clinically relevant to the biological effect is needed. A comparison of published data empirically suggests a basic relationship that may be used to calculate a "thermal dose." From a knowledge of the temperature during treatment as a function of time combined with a mathematical description of the time-temperature relationship, an estimate of the actual treatment calculated as an exposure time at some reference temperature can be determined. This could be of great benefit in providing a real-time accumulated dose during actual patient treatment. For the purpose of this study, a reference temperature of 43 degrees C has been arbitrarily chosen to convert all thermal exposures to "equivalent-minutes" at this temperature. This dose calculation can be compared to an integrated calculation of the "degree-minutes" to determine its prognostic ability. The time-temperature relationship upon which this equivalent dose calculation is based does not predict, nor does it require, that different tissues have the same sensitivity to heat. A computer program written in FORTRAN is included for performing calculations of both equivalent-minutes (t43) and degree-minutes (tdm43). Means are provided to alter the reference temperature, the Arrhenius "break" temperature and the time-temperature relationship both above and below the "break" temperature. In addition, the effect of factors such as step-down heating, thermotolerance, and physiological conditions on thermal dose calculations are discussed. The equations and methods described in this report are not intended to represent the only approach for thermal dose estimation; instead, they are intended to provide a simple but effective means for such calculations for clinical use and to stimulate efforts to evaluate data in terms of therapeutically useful thermal units.
Similar articles
- Arrhenius relationships from the molecule and cell to the clinic.
Dewey WC. Dewey WC. Int J Hyperthermia. 2009 Feb;25(1):3-20. doi: 10.1080/02656730902747919. Int J Hyperthermia. 2009. PMID: 19219695 - Is CEM43 still a relevant thermal dose parameter for hyperthermia treatment monitoring?
van Rhoon GC. van Rhoon GC. Int J Hyperthermia. 2016;32(1):50-62. doi: 10.3109/02656736.2015.1114153. Epub 2016 Jan 12. Int J Hyperthermia. 2016. PMID: 26758036 Review. - Sensitivity of hyperthermia trial outcomes to temperature and time: implications for thermal goals of treatment.
Oleson JR, Samulski TV, Leopold KA, Clegg ST, Dewhirst MW, Dodge RK, George SL. Oleson JR, et al. Int J Radiat Oncol Biol Phys. 1993 Jan 15;25(2):289-97. doi: 10.1016/0360-3016(93)90351-u. Int J Radiat Oncol Biol Phys. 1993. PMID: 8420877 Clinical Trial. - Optimal power deposition patterns for ideal high temperature therapy/hyperthermia treatments.
Cheng KS, Roemer RB. Cheng KS, et al. Int J Hyperthermia. 2004 Feb;20(1):57-72. doi: 10.1080/02656730310001611099. Int J Hyperthermia. 2004. PMID: 14612314 - Magnetic resonance imaging conditionally safe neurostimulation leads: investigation of the maximum safe lead tip temperature.
Coffey RJ, Kalin R, Olsen JM. Coffey RJ, et al. Neurosurgery. 2014 Feb;74(2):215-24; discussion 224-5. doi: 10.1227/NEU.0000000000000242. Neurosurgery. 2014. PMID: 24176957 Review.
Cited by
- Deep Brain Ultrasound Ablation Thermal Dose Modeling with in Vivo Experimental Validation.
Zhao Z, Szewczyk B, Tarasek M, Bales C, Wang Y, Liu M, Jiang Y, Bhushan C, Fiveland E, Campwala Z, Trowbridge R, Johansen PM, Olmsted Z, Ghoshal G, Heffter T, Gandomi K, Tavakkolmoghaddam F, Nycz C, Jeannotte E, Mane S, Nalwalk J, Burdette EC, Qian J, Yeo D, Pilitsis J, Fischer GS. Zhao Z, et al. ArXiv [Preprint]. 2024 Sep 5:arXiv:2409.02395v2. ArXiv. 2024. PMID: 39279835 Free PMC article. Preprint. - Plasma Control: A Review of Developments and Applications of Plasma Medicine Control Mechanisms.
Thomas JE, Stapelmann K. Thomas JE, et al. Plasma (Basel). 2024 Jun;7(2):386-426. doi: 10.3390/plasma7020022. Epub 2024 May 27. Plasma (Basel). 2024. PMID: 39246391 Free PMC article. - Neural modulation with photothermally active nanomaterials.
Wang Y, Garg R, Cohen-Karni D, Cohen-Karni T. Wang Y, et al. Nat Rev Bioeng. 2023 Mar;1(3):193-207. doi: 10.1038/s44222-023-00022-y. Epub 2023 Jan 31. Nat Rev Bioeng. 2023. PMID: 39221032 Free PMC article. - Model based deep learning method for focused ultrasound pathway scanning.
Lari S, Kohandel M, Kwon HJ. Lari S, et al. Sci Rep. 2024 Aug 29;14(1):20042. doi: 10.1038/s41598-024-70689-9. Sci Rep. 2024. PMID: 39198623 Free PMC article. - Combination of US hyperthermia and radiotherapy on a preclinical glioblastoma model.
Durando G, Vurro F, Saba F, Ivory AM, de Melo Baesso R, Miloro P, Spinelli AE. Durando G, et al. Sci Rep. 2024 Aug 27;14(1):19878. doi: 10.1038/s41598-024-70838-0. Sci Rep. 2024. PMID: 39191985 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources