Structure of two human beta-actin-related processed genes one of which is located next to a simple repetitive sequence - PubMed (original) (raw)

Structure of two human beta-actin-related processed genes one of which is located next to a simple repetitive sequence

M Moos et al. EMBO J. 1983.

Abstract

From a human gene library we have isolated and sequenced a beta-actin-like pseudogene, H beta Ac-psi 2, which lacks intervening sequences and contains several mutations resulting in frame-shifts, stop codons and in a departure from the known beta-actin protein sequence. We have also extended our sequence work on the intronless human beta-actin-related pseudogene H beta Ac-psi 1 described previously and we find that both genes are processed genes ending in a poly(dA) tract and flanked by direct repeats. The gene H beta Ac-psi 2 is preceded by a 230-bp region in which the simple sequence 5'-GAAA-3' is repeated greater than 40 times. This satellite-like sequence is highly repetitive in the human genome.

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References

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