Ontogeny of N,N-dimethyltryptamine and related indolealkylamine levels in neonatal rats - PubMed (original) (raw)
Comparative Study
Ontogeny of N,N-dimethyltryptamine and related indolealkylamine levels in neonatal rats
J M Beaton et al. Mech Ageing Dev. 1984 Jun.
Abstract
The present study deals with the measurement of the brain levels of the two potent hallucinogens N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (OMB), the biogenic amine tryptamine (TA), and its condensation product 1,2,3,4-tetrahydro-beta-carboline (THBC) in rats of various ages. Using gas chromatography-mass spectrometry with isotope dilution, we detected DMT, OMB, and THBC in neonatal rats from birth. DMT levels remained low until days 12 and 17 at which time they increased significantly and then returned to the initial low levels for all subsequent ages. The levels of OMB were higher than those measured for DMT with the highest levels being observed at days 12 and 17, and also on day 31. However, the levels for OMB showed much more variation. Although elevated levels of DMT and OMB have been correlated with stress, there are no known functions for these compounds. TA levels remained below detection limits until day 19. THBC levels were observed to be highest on days 22 and 31. The role that THBC plays in mammalian tissues is not known.
Similar articles
- Monoamine oxidase inhibitors in South American hallucinogenic plants: tryptamine and beta-carboline constituents of ayahuasca.
McKenna DJ, Towers GH, Abbott F. McKenna DJ, et al. J Ethnopharmacol. 1984 Apr;10(2):195-223. doi: 10.1016/0378-8741(84)90003-5. J Ethnopharmacol. 1984. PMID: 6587171 - Characterization of the synthesis of N,N-dimethyltryptamine by reductive amination using gas chromatography ion trap mass spectrometry.
Brandt SD, Moore SA, Freeman S, Kanu AB. Brandt SD, et al. Drug Test Anal. 2010 Jul;2(7):330-8. doi: 10.1002/dta.142. Drug Test Anal. 2010. PMID: 20648523 - Hypothetical biosynthetic pathways of pharmaceutically potential hallucinogenic metabolites in Myristicaceae, mechanistic convergence and co-evolutionary trends in plants and humans.
Barman R, Kumar Bora P, Saikia J, Konwar P, Sarkar A, Kemprai P, Proteem Saikia S, Haldar S, Slater A, Banik D. Barman R, et al. Phytochemistry. 2024 Feb;218:113928. doi: 10.1016/j.phytochem.2023.113928. Epub 2023 Nov 29. Phytochemistry. 2024. PMID: 38035973 Review. - N,N-dimethyltryptamine--a possible relationship to schizophrenia?
Wyatt RJ, Gillin JC, Kaplan J, Stillman R, Mandel L, Ahn HS, VandenHeuvel WJ, Walker RW. Wyatt RJ, et al. Adv Biochem Psychopharmacol. 1974;11(0):299-313. Adv Biochem Psychopharmacol. 1974. PMID: 4602668 Review. No abstract available.
Cited by
- Why N,N-dimethyltryptamine matters: unique features and therapeutic potential beyond classical psychedelics.
Chaves C, Dos Santos RG, Dursun SM, Tusconi M, Carta MG, Brietzke E, Hallak JEC. Chaves C, et al. Front Psychiatry. 2024 Nov 6;15:1485337. doi: 10.3389/fpsyt.2024.1485337. eCollection 2024. Front Psychiatry. 2024. PMID: 39568756 Free PMC article. - Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT.
Barker SA. Barker SA. Psychopharmacology (Berl). 2022 Jun;239(6):1749-1763. doi: 10.1007/s00213-022-06065-0. Epub 2022 Jan 22. Psychopharmacology (Berl). 2022. PMID: 35064294 Free PMC article. Review. - A narrative synthesis of research with 5-MeO-DMT.
Ermakova AO, Dunbar F, Rucker J, Johnson MW. Ermakova AO, et al. J Psychopharmacol. 2022 Mar;36(3):273-294. doi: 10.1177/02698811211050543. Epub 2021 Oct 19. J Psychopharmacol. 2022. PMID: 34666554 Free PMC article. Review. - N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo.
Morales-Garcia JA, Calleja-Conde J, Lopez-Moreno JA, Alonso-Gil S, Sanz-SanCristobal M, Riba J, Perez-Castillo A. Morales-Garcia JA, et al. Transl Psychiatry. 2020 Sep 28;10(1):331. doi: 10.1038/s41398-020-01011-0. Transl Psychiatry. 2020. PMID: 32989216 Free PMC article. - Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain.
Dean JG, Liu T, Huff S, Sheler B, Barker SA, Strassman RJ, Wang MM, Borjigin J. Dean JG, et al. Sci Rep. 2019 Jun 27;9(1):9333. doi: 10.1038/s41598-019-45812-w. Sci Rep. 2019. PMID: 31249368 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical