Outline of a theory of cellular heterogeneity - PubMed (original) (raw)
Outline of a theory of cellular heterogeneity
W M Elsasser. Proc Natl Acad Sci U S A. 1984 Aug.
Abstract
In the effort to advance toward a theory of cellular function that is not completely mechanistic, I have encountered a variable whose significance is often overlooked. This is the degree of heterogeneity of organic tissue, which may vary from highly homogeneous conditions to quite large degrees of heterogeneity, primarily with respect ot chemical bonding. For several decades, I have dealt with the theoretical analysis of this type of problem, and here I give a condensed outline of the conceptual changes to which such an analysis is likely to lead. I believe the time is ripe to compare these theoretical arguments with observations. The data that occasion this note are those of Rubin [Rubin, H. (1984) Proc. Natl. Acad. Sci. USA 81, 5121-5125]; they and numerous similar observations suggest the possibility of an advance toward a nonreductionist model of cellular function along lines that are here indicated; the theoretical model is thought of as operating entirely within the framework of quantum mechanics.
Similar articles
- c[D-pro-Pro-D-pro-N-methyl-Ala] adopts a rigid conformation that serves as a scaffold to mimic reverse-turns.
Arbor S, Kao J, Wu Y, Marshall GR. Arbor S, et al. Biopolymers. 2008;90(3):384-93. doi: 10.1002/bip.20869. Biopolymers. 2008. PMID: 17941003 - Quantal release, incremental detection, and long-period Ca2+ oscillations in a model based on regulatory Ca2+-binding sites along the permeation pathway.
Dupont G, Swillens S. Dupont G, et al. Biophys J. 1996 Oct;71(4):1714-22. doi: 10.1016/S0006-3495(96)79373-6. Biophys J. 1996. PMID: 8889149 Free PMC article. - Issues concerning the construction of a metabolic model for neuronal activation.
Mangia S, Giove F, Bianciardi M, Di Salle F, Garreffa G, Maraviglia B. Mangia S, et al. J Neurosci Res. 2003 Feb 15;71(4):463-7. doi: 10.1002/jnr.10531. J Neurosci Res. 2003. PMID: 12548701 Review. - The role of the heme propionates in heme biochemistry.
Guallar V, Olsen B. Guallar V, et al. J Inorg Biochem. 2006 Apr;100(4):755-60. doi: 10.1016/j.jinorgbio.2006.01.019. Epub 2006 Mar 2. J Inorg Biochem. 2006. PMID: 16513175 Review. - An alternative technique for the computation of the designator in the retinex theory of color vision.
Land EH. Land EH. Proc Natl Acad Sci U S A. 1986 May;83(10):3078-80. doi: 10.1073/pnas.83.10.3078. Proc Natl Acad Sci U S A. 1986. PMID: 3458165 Free PMC article.
Cited by
- Single-molecule tracking of myelin basic protein during oligodendrocyte differentiation.
Rassul SM, Otsu M, Styles IB, Neely RK, Fulton D. Rassul SM, et al. Biol Imaging. 2023 Nov 20;3:e24. doi: 10.1017/S2633903X23000259. eCollection 2023. Biol Imaging. 2023. PMID: 38510175 Free PMC article. - Weed biology and management in the multi-omics era: Progress and perspectives.
Chen K, Yang H, Wu D, Peng Y, Lian L, Bai L, Wang L. Chen K, et al. Plant Commun. 2024 Apr 8;5(4):100816. doi: 10.1016/j.xplc.2024.100816. Epub 2024 Jan 12. Plant Commun. 2024. PMID: 38219012 Free PMC article. Review. - Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance.
Maleki EH, Bahrami AR, Matin MM. Maleki EH, et al. Genes Dis. 2023 Jan 14;11(1):189-204. doi: 10.1016/j.gendis.2022.11.025. eCollection 2024 Jan. Genes Dis. 2023. PMID: 37588236 Free PMC article. Review. - Cellular barcoding tracks heterogeneous clones through selective pressures and phenotypic transitions.
Howland KK, Brock A. Howland KK, et al. Trends Cancer. 2023 Jul;9(7):591-601. doi: 10.1016/j.trecan.2023.03.008. Epub 2023 Apr 25. Trends Cancer. 2023. PMID: 37105856 Free PMC article. Review. - Advances in Mass Spectrometry-Based Single Cell Analysis.
Lee S, Vu HM, Lee JH, Lim H, Kim MS. Lee S, et al. Biology (Basel). 2023 Mar 2;12(3):395. doi: 10.3390/biology12030395. Biology (Basel). 2023. PMID: 36979087 Free PMC article. Review.
References
- J Theor Biol. 1981 Mar 7;89(1):131-50 - PubMed
- Proc Natl Acad Sci U S A. 1984 Aug;81(16):5121-5 - PubMed
- J Theor Biol. 1982 May 7;96(1):67-76 - PubMed
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources