Regulation of lymphocyte production in the bone marrow. I. Turnover of small lymphocytes in mice depleted of B lymphocytes by treatment with anti-IgM antibodies - PubMed (original) (raw)
- PMID: 6600249
Regulation of lymphocyte production in the bone marrow. I. Turnover of small lymphocytes in mice depleted of B lymphocytes by treatment with anti-IgM antibodies
G Fulop et al. J Immunol. 1983 Feb.
Abstract
To examine the concept that the genesis of lymphocytes in the bone marrow may be regulated by homeostatic feedback signals from peripheral B lymphocytes or their products, lymphocyte production was measured in mice selectively depleted of B lymphocytes by repeated administration of anti-IgM antibodies from birth. The turnover of small lymphocytes was quantitated radioautographically after DNA labeling by continuous infusion of 3H-thymidine. In the femoral marrow of anti-IgM-treated mice, the number of small lymphocytes was reduced and their turnover time was shorter than in control mice, presumably reflecting the premature elimination from the marrow of maturing cells about to express surface IgM. The absolute number of small lymphocytes being produced per femur in unit time, however, was identical in anti-IgM-treated and control mice. Lymphocyte production in the thymus was also unaffected by anti-IgM suppression whereas in the spleen the turnover of small lymphocytes was reduced due to the lack of young immigrant B lymphocytes from the bone marrow. The results demonstrate that the normal large-scale production of lymphocytes in mouse bone marrow is independent of the magnitude of the peripheral pool of B lymphocytes or the level of circulating immunoglobulins, suggesting the process is not subject to feedback control. Some implications for the genesis and diversity of primary B lymphocytes are discussed.
Similar articles
- Modulation of rat B cell differentiation in vivo by the administration of an anti-mu monoclonal antibody.
Soares M, Havaux X, Nisol F, Bazin H, Latinne D. Soares M, et al. J Immunol. 1996 Jan 1;156(1):108-18. J Immunol. 1996. PMID: 8598450 - Regulation and localization of lymphocyte production in the bone marrow.
Osmond DG, Fahlman MT, Fulop GM, Rahal DM. Osmond DG, et al. Ciba Found Symp. 1981;84:68-86. doi: 10.1002/9780470720660.ch5. Ciba Found Symp. 1981. PMID: 7023878 Review.
Cited by
- Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020.
Tiegs SL, Russell DM, Nemazee D. Tiegs SL, et al. J Immunol. 2011 Feb 1;186(3):1313-24. J Immunol. 2011. PMID: 21248269 Free PMC article. - LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway.
Wang Y, Liu J, Akatsu C, Zhang R, Zhang H, Zhu H, Liu K, Zhu HY, Min Q, Meng X, Cui C, Tang Y, Yu M, Li Y, Feng X, Wei H, Wen Z, Ji S, Weigert MG, Tsubata T, Wang JY. Wang Y, et al. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2205629119. doi: 10.1073/pnas.2205629119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037365 Free PMC article. - Development of pre-B and B lymphocytes in the human fetus.
Asma GE, Langlois van den Bergh R, Vossen JM. Asma GE, et al. Clin Exp Immunol. 1984 May;56(2):407-14. Clin Exp Immunol. 1984. PMID: 6610515 Free PMC article. - Receptor editing in self-reactive bone marrow B cells.
Tiegs SL, Russell DM, Nemazee D. Tiegs SL, et al. J Exp Med. 1993 Apr 1;177(4):1009-20. doi: 10.1084/jem.177.4.1009. J Exp Med. 1993. PMID: 8459201 Free PMC article.