IgE synthesis in vitro induced by T cell factors from patients with elevated serum IgE levels - PubMed (original) (raw)
- PMID: 6602674
- PMCID: PMC1535572
IgE synthesis in vitro induced by T cell factors from patients with elevated serum IgE levels
S Romagnani et al. Clin Exp Immunol. 1983 Apr.
Abstract
The effect of unstimulated T cell culture supernatants (TCS) from patients with atopic dermatitis and high serum IgE levels on the IgE production in vitro by B cell rich suspensions from normal individuals or grass pollen sensitive patients with mild atopy was evaluated. TCS from patients with raised IgE enabled B cell suspensions from normal individuals to produce detectable amounts of IgE and potentiated the spontaneous IgE synthesis in vitro by B cell suspensions from grass sensitive patients. In contrast, the addition of TCS from normal subjects with low serum IgE levels did not increase or even reduced IgE synthesis by B cell cultures. When the same B cell cultures were analysed for their ability to produce IgG or IgM protein, no significant differences were observed. These findings indicate that T lymphocytes from patients with high serum IgE levels can release soluble factor(s) possessing isotype (IgE) specific potentiating activity.
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References
- J Immunol. 1973 Sep;111(3):720-32 - PubMed
- Int Arch Allergy Appl Immunol. 1979;59(2):135-42 - PubMed
- J Immunol. 1979 May;122(5):2131-3 - PubMed
- J Immunol. 1979 Jun;122(6):2184-90 - PubMed
- J Immunol. 1979 Aug;123(2):918-24 - PubMed