The need for randomization in the study of intended effects - PubMed (original) (raw)
Comparative Study
. 1983 Apr-Jun;2(2):267-71.
doi: 10.1002/sim.4780020222.
- PMID: 6648141
- DOI: 10.1002/sim.4780020222
Comparative Study
The need for randomization in the study of intended effects
O S Miettinen. Stat Med. 1983 Apr-Jun.
Abstract
The need for randomization as a means of controlling confounders is accentuated in the study of intended effects (efficacy) as compared with unintended ones (toxicity). The basic reason is that the indication for intervention is inherently a confounder in the study of efficacy but not of toxicity, whereas contraindications represent only a minor confounder even in toxicity research. Moreover, control of the indication in non-experimental terms is commonly infeasible owing to the complexity and subtlety of the indication.
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