Treatment of immature and mature Fasciola hepatica infections in sheep with triclabendazole - PubMed (original) (raw)

Comparative Study

. 1983 Oct 1;113(14):315-7.

doi: 10.1136/vr.113.14.315.

Comparative Study

Treatment of immature and mature Fasciola hepatica infections in sheep with triclabendazole

J C Boray et al. Vet Rec. 1983.

Abstract

A new benzimidazole anthelmintic, triclabendazole (CGA-89317) was found to be highly efficient against mature and early immature Fasciola hepatica infections in sheep. At the dose rate of 2.5 mg/kg the efficiency was 90 and 98 per cent against flukes aged eight and 12 weeks respectively. At 5 mg/kg the drug was 92 and 98 per cent efficient against flukes aged four and eight weeks respectively and 100 per cent against 12-week-old flukes. An efficiency of 93 and 98 per cent was achieved against one-week-old flukes and 99 to 100 per cent against flukes aged two to four weeks at 10 mg/kg. At this dose rate the drug had 100 per cent efficiency against six-week-old flukes. If the dose was increased to 15 mg/kg, 98 per cent efficiency was achieved one day after infection. Triclabendazole was equally efficient when administered orally or by intraruminal or intra-abomasal injection. The maximum tolerated dose of 200 mg/kg was established.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources