Aminoglycoside modification by gentamicin-resistant isolates of Staphylococcus aureus - PubMed (original) (raw)
Aminoglycoside modification by gentamicin-resistant isolates of Staphylococcus aureus
D F Scott et al. Antimicrob Agents Chemother. 1978 Apr.
Abstract
Three clinical isolates of Staphylococcus aureus, which were previously shown to contain a 50S plasmid conferring resistance to several aminoglycosides, were examined for modifying enzymes. Both the wild-type and heat-cured derivatives of the isolates were screened for acetyl-, adenylyl-, and phosphotransferase activities. The substrates were gentamicin, amikacin, and netilmicin; the results indicated that even though all three activites were present, the phosphotransferase reaction was most responsible for resistance to these antibiotics. The absence of any of the modifying activites in cured derivatives of the three isolates supports the conclusion that aminoglycoside resistance in these strains is conferred by a plasmid.
Similar articles
- Mechanisms of gentamicin resistance in Staphylococcus aureus.
Dowding JE. Dowding JE. Antimicrob Agents Chemother. 1977 Jan;11(1):47-50. doi: 10.1128/AAC.11.1.47. Antimicrob Agents Chemother. 1977. PMID: 836013 Free PMC article. - Selection of subpopulations resistnat to amikacin and netilmicin of gentamicin-resistant clinical strains of Staphylococcus aureus and Staphylococcus epidermidis.
Torres García M, Tejedor Junco MT, González Martín M, González Lama Z. Torres García M, et al. Zentralbl Bakteriol. 1996 Jun;284(1):58-66. doi: 10.1016/s0934-8840(96)80154-x. Zentralbl Bakteriol. 1996. PMID: 8837369 - Trends in the gentamicin and arbekacin susceptibility of methicillin-resistant Staphylococcus aureus and the genes encoding aminoglycoside-modifying enzymes.
Barada K, Hanaki H, Ikeda S, Yamaguchi Y, Akama H, Nakae T, Inamatsu T, Sunakawa K. Barada K, et al. J Infect Chemother. 2007 Apr;13(2):74-8. doi: 10.1007/s10156-006-0497-0. Epub 2007 May 8. J Infect Chemother. 2007. PMID: 17458673 - Stability of aminoglycoside resistance in vitro in gentamicin-resistant Staphylococcus aureus.
Dixson S, Brumfitt W, Hamilton-Miller JM. Dixson S, et al. J Hyg (Lond). 1984 Aug;93(1):43-9. doi: 10.1017/s0022172400060915. J Hyg (Lond). 1984. PMID: 6747285 Free PMC article. - Problems in in vitro determination of antibiotic tolerance in clinical isolates.
Sherris JC. Sherris JC. Antimicrob Agents Chemother. 1986 Nov;30(5):633-7. doi: 10.1128/AAC.30.5.633. Antimicrob Agents Chemother. 1986. PMID: 3541781 Free PMC article. Review. No abstract available.
Cited by
- Antimicrobial resistance of Staphylococcus aureus: genetic basis.
Lyon BR, Skurray R. Lyon BR, et al. Microbiol Rev. 1987 Mar;51(1):88-134. doi: 10.1128/mr.51.1.88-134.1987. Microbiol Rev. 1987. PMID: 3031442 Free PMC article. Review. No abstract available. - Determination of aminoglycoside resistance in Staphylococcus aureus by DNA hybridization.
Dickgiesser N, Kreiswirth BN. Dickgiesser N, et al. Antimicrob Agents Chemother. 1986 May;29(5):930-2. doi: 10.1128/AAC.29.5.930. Antimicrob Agents Chemother. 1986. PMID: 3729351 Free PMC article. - Intergeneric and interspecies gene exchange in gram-positive cocci.
Schaberg DR, Zervos MJ. Schaberg DR, et al. Antimicrob Agents Chemother. 1986 Dec;30(6):817-22. doi: 10.1128/AAC.30.6.817. Antimicrob Agents Chemother. 1986. PMID: 3028249 Free PMC article. Review. No abstract available. - Comparison of epidemiological markers used in the investigation of an outbreak of methicillin-resistant Staphylococcus aureus infections.
Archer GL, Mayhall CG. Archer GL, et al. J Clin Microbiol. 1983 Aug;18(2):395-9. doi: 10.1128/jcm.18.2.395-399.1983. J Clin Microbiol. 1983. PMID: 6619288 Free PMC article. - Self-transmissible plasmids in staphylococci that encode resistance to aminoglycosides.
Archer GL, Johnston JL. Archer GL, et al. Antimicrob Agents Chemother. 1983 Jul;24(1):70-7. doi: 10.1128/AAC.24.1.70. Antimicrob Agents Chemother. 1983. PMID: 6625557 Free PMC article.
References
- Lancet. 1976 Aug 21;2(7982):419 - PubMed
- Antimicrob Agents Chemother. 1977 Mar;11(3):402-6 - PubMed
- Antimicrob Agents Chemother. 1977 Oct;12(4):513-7 - PubMed
- Antimicrob Agents Chemother. 1977 Jul;12(1):26-30 - PubMed
- Am J Med. 1977 Jun;62(6):868-72 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources