Discriminant analysis of the localization of aggression-inducing electrode placements in the hypothalamus of male rats - PubMed (original) (raw)
Discriminant analysis of the localization of aggression-inducing electrode placements in the hypothalamus of male rats
M R Kruk et al. Brain Res. 1983.
Abstract
Over 400 sites in the hypothalami of 270 male CPB/WE-zob rats were electrically stimulated in order to induce fights between males. The localization of electrodes inducing fights seems to differ from the localization of electrodes in which no fights can be induced. The differences in localization were detected and tested by a non-parametric discriminant analysis. The results were plotted by computer in a stereotaxic atlas of the hypothalamus of the CPB/WE strain. The method delimits areas within the hypothalamus where the probability to induce aggression is high, intermediate or low. Moreover, the procedure allows discrimination between areas where the thresholds for attack behaviour are generally lower than elsewhere and where the fiercest forms of attack are induced. None of the areas delimited coincide with a classical subdivision of the hypothalamus. Parts of the perifornical, anterior, lateral and ventromedial hypothalamus seem to be involved. The methods developed here may help to relate stimulation-induced aggression to other characteristics of the 'aggressive' area which cannot be obtained directly from fighting rats such as cytological, endocrinological, biochemical or physiological data. In addition, the procedure may help to settle disputes on the specificity of the localization of neural substrates of other stimulation-induced behaviours. The methods to discriminate between overlapping 3-dimensional reconstructions validated here for aggressive responses, can also be applied to other types of stereotaxic data and other types of effects, such as electrical, hormonal or other physiological responses. They may be especially useful if the localization of the neural population involved is not yet known, and unknown current-spread or diffusion of substances complicates the interpretation of stereotaxic data.
Similar articles
- Hypothalamic substrates for brain stimulation-induced attack, teeth-chattering and social grooming in the rat.
Lammers JH, Kruk MR, Meelis W, van der Poel AM. Lammers JH, et al. Brain Res. 1988 May 24;449(1-2):311-27. doi: 10.1016/0006-8993(88)91046-3. Brain Res. 1988. PMID: 3395851 - Hypothalamic substrates for brain stimulation-induced grooming, digging and circling in the rat.
Lammers JH, Meelis W, Kruk MR, van der Poel AM. Lammers JH, et al. Brain Res. 1987 Aug 18;418(1):1-19. doi: 10.1016/0006-8993(87)90956-5. Brain Res. 1987. PMID: 3664265 - Threat, attack and flight elicited by electrical stimulation of the ventromedial hypothalamus of the marmoset monkey Callithrix jacchus.
Lipp HP, Hunsperger RW. Lipp HP, et al. Brain Behav Evol. 1978;15(4):260-93. doi: 10.1159/000123782. Brain Behav Evol. 1978. PMID: 100172 - The organization of intraspecific agonistic behaviour in the rat.
Koolhaas JM, Schuurman T, Wiepkema PR. Koolhaas JM, et al. Prog Neurobiol. 1980;15(3):247-68. doi: 10.1016/0301-0082(80)90024-6. Prog Neurobiol. 1980. PMID: 7005965 Review. No abstract available. - Hypothalamic attack: a wonderful artifact or a useful perspective on escalation and pathology in aggression? A viewpoint.
Kruk MR. Kruk MR. Curr Top Behav Neurosci. 2014;17:143-88. doi: 10.1007/7854_2014_313. Curr Top Behav Neurosci. 2014. PMID: 24852798 Review.
Cited by
- Aggression Unleashed: Neural Circuits from Scent to Brain.
Singh R, Gobrogge K. Singh R, et al. Brain Sci. 2024 Aug 8;14(8):794. doi: 10.3390/brainsci14080794. Brain Sci. 2024. PMID: 39199486 Free PMC article. Review. - Maternal Aggression Driven by the Transient Mobilisation of a Dormant Hormone-Sensitive Circuit.
Stagkourakis S, Williams P, Spigolon G, Khanal S, Ziegler K, Heikkinen L, Fisone G, Broberger C. Stagkourakis S, et al. bioRxiv [Preprint]. 2024 Mar 31:2023.02.02.526862. doi: 10.1101/2023.02.02.526862. bioRxiv. 2024. PMID: 38585740 Free PMC article. Preprint. - Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior.
McLachlan IG, Kramer TS, Dua M, DiLoreto EM, Gomes MA, Dag U, Srinivasan J, Flavell SW. McLachlan IG, et al. Elife. 2022 Aug 31;11:e79557. doi: 10.7554/eLife.79557. Elife. 2022. PMID: 36044259 Free PMC article. - From Reductionism Toward Integration: Understanding How Social Behavior Emerges From Integrated Circuits.
Dickinson SY, Kelly DA, Padilla SL, Bergan JF. Dickinson SY, et al. Front Integr Neurosci. 2022 Apr 1;16:862437. doi: 10.3389/fnint.2022.862437. eCollection 2022. Front Integr Neurosci. 2022. PMID: 35431824 Free PMC article. Review. - Sex Differences in Aggression Are Paralleled by Differential Activation of the Brain Social Decision-Making Network in Zebrafish.
Scaia MF, Akinrinade I, Petri G, Oliveira RF. Scaia MF, et al. Front Behav Neurosci. 2022 Feb 16;16:784835. doi: 10.3389/fnbeh.2022.784835. eCollection 2022. Front Behav Neurosci. 2022. PMID: 35250500 Free PMC article.