Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes - PubMed (original) (raw)
Comparative Study
Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes
C E Mogensen. N Engl J Med. 1984.
Abstract
We studied whether microalbuminuria (30 to 140 micrograms of albumin per milliliter) would predict the later development of increased proteinuria and early mortality in Type II diabetics. During 1973, morning urine specimens of diabetic clinic patients 50 to 75 years of age whose disease had been diagnosed the age of 45 were examined for albumin level by radioimmunoassay. Seventy-six patients with albumin concentrations of 30 to 140 micrograms per milliliter were identified for long-term follow-up. They were compared with normal controls, diabetic patients with lower albumin concentrations (75 patients with concentrations less than 15 micrograms per milliliter and 53 with concentrations of 16 to 29 micrograms per milliliter), and 28 diabetic patients with higher concentrations (greater than 140). Age, duration of diabetes, treatment method, fasting blood glucose level, blood pressure, height, and weight were determined for the four diabetic groups. After nine years the group with albumin concentrations of 30 to 140 micrograms per milliliter was more likely to have clinically detectable proteinuria (greater than 400 micrograms per milliliter) than were the groups with lower concentrations. Mortality was 148 per cent higher in this group than in normal controls--comparable to the increase (116 per cent) in the group with heavy proteinuria (albumin levels greater than 140 micrograms per milliliter). In addition, mortality was increased 76 per cent in the group with albumin levels of 16 to 29 micrograms per milliliter and 37 per cent in the group with levels below 15. We conclude that microalbuminuria in patients with Type II diabetes is predictive of clinical proteinuria and increased mortality.
Similar articles
- Predicting diabetic nephropathy in insulin-dependent patients.
Mogensen CE, Christensen CK. Mogensen CE, et al. N Engl J Med. 1984 Jul 12;311(2):89-93. doi: 10.1056/NEJM198407123110204. N Engl J Med. 1984. PMID: 6738599 - Microalbuminuria in non-insulin-dependent diabetes.
Mogensen CE, Damsgaard EM, Frøland A, Nielsen S, de Fine Olivarius N, Schmitz A. Mogensen CE, et al. Clin Nephrol. 1992;38 Suppl 1:S28-39. Clin Nephrol. 1992. PMID: 1295705 Review. - Long-term mortality and retinopathy in type 1 diabetes.
Grauslund J. Grauslund J. Acta Ophthalmol. 2010 May;88 Thesis1:1-14. doi: 10.1111/j.1755-3768.2010.01906.x. Acta Ophthalmol. 2010. PMID: 20500731 - Relationships among microalbuminuria, insulin resistance and renal-cardiac complications in insulin dependent and non insulin dependent diabetes.
Nosadini R, Brocco E. Nosadini R, et al. Exp Clin Endocrinol Diabetes. 1997;105 Suppl 2:1-7. doi: 10.1055/s-0029-1211783. Exp Clin Endocrinol Diabetes. 1997. PMID: 9288531 Review. - [Diabetic nephropathy: significance of microalbuminuria and proteinuria in Type I and Type II diabetes mellitus].
Lehmann R, Spinas GA. Lehmann R, et al. Praxis (Bern 1994). 1995 Oct 31;84(44):1265-71. Praxis (Bern 1994). 1995. PMID: 7491450 Review. German.
Cited by
- Early Diagnosis and Treatment of Kidney Injury: A Focus on Urine Protein.
Zeng D, Wang B, Xiao Z, Wang X, Tang X, Yao X, Wang P, Li M, Dai Y, Yu X. Zeng D, et al. Int J Mol Sci. 2024 Oct 17;25(20):11171. doi: 10.3390/ijms252011171. Int J Mol Sci. 2024. PMID: 39456955 Free PMC article. Review. - Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes.
Persson MF, Franzén S, Catrina SB, Dallner G, Hansell P, Brismar K, Palm F. Persson MF, et al. Diabetologia. 2012 May;55(5):1535-43. doi: 10.1007/s00125-012-2469-5. Epub 2012 Feb 5. Diabetologia. 2012. PMID: 22311417 - Long-term follow-up of the remaining kidney in living related kidney donors.
Sobh M, Nabeeh A, el-Din AS, el-Housseiny, Ibrahiem I, el-Kenavy M, Elhamady S, Fayed S, Arafat N, Ghoneim M. Sobh M, et al. Int Urol Nephrol. 1989;21(5):547-53. doi: 10.1007/BF02549594. Int Urol Nephrol. 1989. PMID: 2613485 - Proteinuria: value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus.
Borch-Johnsen K, Kreiner S. Borch-Johnsen K, et al. Br Med J (Clin Res Ed). 1987 Jun 27;294(6588):1651-4. doi: 10.1136/bmj.294.6588.1651. Br Med J (Clin Res Ed). 1987. PMID: 3113569 Free PMC article. - Kidney function in adults born with unilateral renal agenesis or nephrectomized in childhood.
Wikstad I, Celsi G, Larsson L, Herin P, Aperia A. Wikstad I, et al. Pediatr Nephrol. 1988 Apr;2(2):177-82. doi: 10.1007/BF00862585. Pediatr Nephrol. 1988. PMID: 3153008
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical