Effect of long-chain fatty acyl-CoA on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell - PubMed (original) (raw)
Effect of long-chain fatty acyl-CoA on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell
S Soboll et al. Biochem J. 1984.
Abstract
The effect of long-chain acyl-CoA on subcellular adenine nucleotide systems was studied in the intact liver cell. Long-chain acyl-CoA content was varied by varying the nutritional state (fed and starved states) or by addition of oleate. Starvation led to an increase in the mitochondrial and a decrease in the cytosolic ATP/ADP ratio in liver both in vivo and in the isolated perfused organ as compared with the fed state. The changes were reversed on re-feeding glucose in liver in vivo or on infusion of substrates (glucose, glycerol) in the perfused liver, respectively. Similar changes in mitochondrial and cytosolic ATP/ADP ratios occurred on addition of oleate, but, importantly, not with a short-chain fatty acid such as octanoate. It is concluded that long-chain acyl-CoA exerts an inhibitory effect on mitochondrial adenine nucleotide translocation in the intact cell, as was previously postulated in the literature from data obtained with isolated mitochondria. The physiological relevance with respect to pyruvate metabolism, i.e. regulation of pyruvate carboxylase and pyruvate dehydrogenase by the mitochondrial ATP/ADP ratio, is discussed.
Similar articles
- Rapid thyroid-hormone effect on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell.
Seitz HJ, Müller MJ, Soboll S. Seitz HJ, et al. Biochem J. 1985 Apr 1;227(1):149-53. doi: 10.1042/bj2270149. Biochem J. 1985. PMID: 3994679 Free PMC article. - Phosphorylation state of cytosolic and mitochondrial adenine nucleotides and of pyruvate dehydrogenase in isolated rat liver cells.
Siess EA, Wieland OH. Siess EA, et al. Biochem J. 1976 Apr 15;156(1):91-102. doi: 10.1042/bj1560091. Biochem J. 1976. PMID: 133678 Free PMC article. - Subcellular metabolite concentrations. Dependence of mitochondrial and cytosolic ATP systems on the metabolic state of perfused rat liver.
Soboll S, Scholz R, Heldt HW. Soboll S, et al. Eur J Biochem. 1978 Jun 15;87(2):377-90. doi: 10.1111/j.1432-1033.1978.tb12387.x. Eur J Biochem. 1978. PMID: 668699 - The effect of long chain fatty acyl CoA esters on the adenine nucleotide translocase and myocardial metabolism.
Shrago E. Shrago E. Life Sci. 1978 Jan;22(1):1-5. doi: 10.1016/0024-3205(78)90403-4. Life Sci. 1978. PMID: 342854 Review. No abstract available. - The interaction of long-chain acyl CoA with membranes.
Brecher P. Brecher P. Mol Cell Biochem. 1983;57(1):3-15. doi: 10.1007/BF00223520. Mol Cell Biochem. 1983. PMID: 6358858 Review.
Cited by
- An Uncommon Phosphorylation Mode Regulates the Activity and Protein Interactions of _N_-Acetylglucosamine Kinase.
Celik A, Beyer I, Fiedler D. Celik A, et al. J Am Chem Soc. 2024 May 29;146(21):14807-14815. doi: 10.1021/jacs.4c03069. Epub 2024 May 11. J Am Chem Soc. 2024. PMID: 38733353 Free PMC article. - Defining the effects of storage on platelet bioenergetics: The role of increased proton leak.
Ravi S, Chacko B, Kramer PA, Sawada H, Johnson MS, Zhi D, Marques MB, Darley-Usmar VM. Ravi S, et al. Biochim Biophys Acta. 2015 Nov;1852(11):2525-34. doi: 10.1016/j.bbadis.2015.08.026. Epub 2015 Aug 29. Biochim Biophys Acta. 2015. PMID: 26327682 Free PMC article. - Liposomes as fatty acids carriers in isolated rat liver: effect on energy metabolism and on isolated mitochondria activity.
Delmas-Beauvieux MC, Leducq N, Thiaudière E, Diolez P, Gin H, Canioni P, Gallis JL. Delmas-Beauvieux MC, et al. MAGMA. 2000 Feb;10(1):43-51. doi: 10.1007/BF02613111. MAGMA. 2000. PMID: 10697225 - Regulation of energy metabolism in liver.
Soboll S. Soboll S. J Bioenerg Biomembr. 1995 Dec;27(6):571-82. doi: 10.1007/BF02111655. J Bioenerg Biomembr. 1995. PMID: 8746844 Review. - Rapid thyroid-hormone effect on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell.
Seitz HJ, Müller MJ, Soboll S. Seitz HJ, et al. Biochem J. 1985 Apr 1;227(1):149-53. doi: 10.1042/bj2270149. Biochem J. 1985. PMID: 3994679 Free PMC article.
References
- Biochem J. 1980 Dec 15;192(3):951-4 - PubMed
- Arch Biochem Biophys. 1977 Oct;183(2):647-63 - PubMed
- Biochem Biophys Res Commun. 1963 Sep 10;13:26-31 - PubMed
- J Biol Chem. 1961 Oct;236:2560-5 - PubMed
- J Bioenerg Biomembr. 1976 Dec;8(6):293-311 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources