PEP4 gene function is required for expression of several vacuolar hydrolases in Saccharomyces cerevisiae - PubMed (original) (raw)

PEP4 gene function is required for expression of several vacuolar hydrolases in Saccharomyces cerevisiae

E W Jones et al. Genetics. 1982 Dec.

Abstract

The pep4-3 mutation results in a 90-95% reduction in the levels of five vacuolar hydrolases in yeast, including proteinases A and B, carboxypeptidase Y, RNase(s) and the repressible alkaline phosphatase. The mutation is without effect on two secreted glycoproteins, on an enzyme of the vacuolar membrane, and on a proteinase located outside of the vacuole. Mutations at the PEP4 locus exhibit a dosage effect on the levels of some, but not all, of the enzymes whose expression requires the function of the gene.

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References

1. 1. Biochim Biophys Acta. 1978 May 11;524(1):121-30 - PubMed
2. 1. Genetics. 1977 Jan;85(1):23-33 - PubMed
3. 1. Biochim Biophys Acta. 1976 Mar 25;428(1):182-92 - PubMed
4. 1. J Ultrastruct Res. 1975 Feb;50(2):208-15 - PubMed
5. 1. Biochem Biophys Res Commun. 1974 Oct 23;60(4):1378-83 - PubMed

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