Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes - PubMed (original) (raw)

. 1980 Apr 25;255(8):3691-4.

• PMID: 6767723

Free article

Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes

Y Nishioka et al. J Biol Chem. 1980.

Free article

Abstract

We have determined the entire sequence of two immunoglobulin kappa variable region genes derived separately from embryonic and plasmacytoma cells. Both genes are in the germline configuration; both are organized into hydrophobic leader and mature V-region coding sequences separated by a short intervening sequence. Both are identical with one another throughout the 1360 bases determined. In addition, there is a simple repeat sequence of 31 CA doublets that occurs about 300 bases from the 3' side of the coding sequence in each gene.

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