Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects - PubMed (original) (raw)
Clinical Trial
Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects
K M Laurence et al. Br Med J (Clin Res Ed). 1981.
Abstract
A randomized controlled double-blind trial was undertaken in south Wales to prevent the recurrence of neural-tube defects in women who had had one child with a neural-tube defect. Sixty women were allocated before conception to take 4 mg of folic acid a day before and during early pregnancy and 44 complied with these instructions. Fifty-one women were allocated to placebo treatment. There were no recurrences among the compliant mothers but two among the non-compliers and four among the women in the placebo group. Thus there were no recurrences among those who received supplementation and six among those who did not; this difference is significant (p = 0.04). It is concluded that folic acid supplementation might be a cheap, safe, and effective method of primary prevention of neural-tube defects but that this must be confirmed in a large, multicentre trial.
Similar articles
- Inositol for the prevention of neural tube defects: a pilot randomised controlled trial.
Greene ND, Leung KY, Gay V, Burren K, Mills K, Chitty LS, Copp AJ. Greene ND, et al. Br J Nutr. 2016 Mar 28;115(6):974-83. doi: 10.1017/S0007114515005322. Epub 2016 Feb 5. Br J Nutr. 2016. PMID: 26847388 Free PMC article. Clinical Trial. - Prevention of neural tube defects by improvement in maternal diet and preconceptional folic acid supplementation.
Laurence KM. Laurence KM. Prog Clin Biol Res. 1985;163B:383-8. Prog Clin Biol Res. 1985. PMID: 3885240 Clinical Trial. No abstract available. - Folate supplements prevent recurrence of neural tube defects.
[No authors listed] [No authors listed] Nutr Rev. 1992 Jan;50(1):22-4. doi: 10.1111/j.1753-4887.1992.tb02459.x. Nutr Rev. 1992. PMID: 1579267 Review. - Prevention of neural tube defects with periconceptional folic acid.
Rieder MJ. Rieder MJ. Clin Perinatol. 1994 Sep;21(3):483-503. Clin Perinatol. 1994. PMID: 7982331 Review.
Cited by
- Awareness of Periconceptional Folic Acid in Parents of Children Affected by Spina Bifida - A Pilot Study.
Vashisht RG, Dasaratha V, Santahanakrishna R. Vashisht RG, et al. Afr J Paediatr Surg. 2024 Apr 1;21(2):107-110. doi: 10.4103/ajps.ajps_102_22. Epub 2023 Feb 14. Afr J Paediatr Surg. 2024. PMID: 38546248 Free PMC article. - Spina Bifida Prevention: A Narrative Review of Folic Acid Supplements for Childbearing Age Women.
Ledet Iii LF, Plaisance CJ, Daniel CP, Wagner MJ, Alvarez I, Burroughs CR, Rieger R, Siddaiah H, Ahmadzadeh S, Shekoohi S, Kaye AD, Varrassi G. Ledet Iii LF, et al. Cureus. 2024 Jan 26;16(1):e53008. doi: 10.7759/cureus.53008. eCollection 2024 Jan. Cureus. 2024. PMID: 38406082 Free PMC article. Review. - Before Is Better: Innovative Multidisciplinary Preconception Care in Different Clinical Contexts.
Cristodoro M, Dell'Avanzo M, Ghio M, Lalatta F, Vena W, Lania A, Sacchi L, Bravo M, Bulfoni A, Di Simone N, Inversetti A. Cristodoro M, et al. J Clin Med. 2023 Oct 3;12(19):6352. doi: 10.3390/jcm12196352. J Clin Med. 2023. PMID: 37834996 Free PMC article. Review. - Maternal metabolism influences neural tube closure.
Keuls RA, Finnell RH, Parchem RJ. Keuls RA, et al. Trends Endocrinol Metab. 2023 Sep;34(9):539-553. doi: 10.1016/j.tem.2023.06.005. Epub 2023 Jul 17. Trends Endocrinol Metab. 2023. PMID: 37468429 Free PMC article. Review. - Myelomeningocele: the evolution of care over the last 50 years.
Bowman RM, Lee JY, Yang J, Kim KH, Wang KC. Bowman RM, et al. Childs Nerv Syst. 2023 Oct;39(10):2829-2845. doi: 10.1007/s00381-023-06057-1. Epub 2023 Jul 7. Childs Nerv Syst. 2023. PMID: 37417984 Review.
References
- J Clin Pathol. 1966 Jan;19(1):17-28 - PubMed
- Br J Prev Soc Med. 1968 Jul;22(3):146-60 - PubMed
- Br J Prev Soc Med. 1968 Oct;22(4):212-22 - PubMed
- Am J Obstet Gynecol. 1952 Jun;63(6):1298-304 - PubMed
- Arch Dis Child. 1976 Dec;51(12):944-50 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical