Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects - PubMed (original) (raw)

Clinical Trial

Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects

K M Laurence et al. Br Med J (Clin Res Ed). 1981.

Abstract

A randomized controlled double-blind trial was undertaken in south Wales to prevent the recurrence of neural-tube defects in women who had had one child with a neural-tube defect. Sixty women were allocated before conception to take 4 mg of folic acid a day before and during early pregnancy and 44 complied with these instructions. Fifty-one women were allocated to placebo treatment. There were no recurrences among the compliant mothers but two among the non-compliers and four among the women in the placebo group. Thus there were no recurrences among those who received supplementation and six among those who did not; this difference is significant (p = 0.04). It is concluded that folic acid supplementation might be a cheap, safe, and effective method of primary prevention of neural-tube defects but that this must be confirmed in a large, multicentre trial.

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References

    1. J Clin Pathol. 1966 Jan;19(1):17-28 - PubMed
    1. Br J Prev Soc Med. 1968 Jul;22(3):146-60 - PubMed
    1. Br J Prev Soc Med. 1968 Oct;22(4):212-22 - PubMed
    1. Am J Obstet Gynecol. 1952 Jun;63(6):1298-304 - PubMed
    1. Arch Dis Child. 1976 Dec;51(12):944-50 - PubMed

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