An investigation of the clonality of human autoimmune thyroglobulin antibodies and their light chains - PubMed (original) (raw)

• PMID: 6802536
• PMCID: PMC1536335

An investigation of the clonality of human autoimmune thyroglobulin antibodies and their light chains

L Nye et al. Clin Exp Immunol. 1981 Oct.

Abstract

Thyroglobulin antibodies in the sera from 31 patients with a variety of disorders were studied by isoelectric focusing. Only one gave a spectrotype indicative of a monoclonal response, the other 30 giving spectrotypes characteristic of polyclonal responses. There was evidence of clonal dominance in some of the sera and each gave a different spectrotype. Light chains were prepared from five thyroglobulin antibodies purified by affinity chromatography. There was no restriction in the spectrotypes when compared with light chains prepared from normal immunoglobulin.

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