Human c-Ki-ras2 proto-oncogene on chromosome 12 - PubMed (original) (raw)
Human c-Ki-ras2 proto-oncogene on chromosome 12
A Y Sakaguchi et al. Science. 1983.
Abstract
A human colonic adenocarcinoma transforming gene, recently identified as a cellular homolog of the Kirsten sarcoma gene (v-ras), was used to assign the human cellular Kirsten ras2 gene to chromosome 12 by the Southern hybridization method. A single 640 base-pair Eco RI--Hind III fragment of the transforming gene, isolated by DNA transfection and molecular cloning, can detect a single Eco RI fragment (2.9 kilobase pairs) of DNA from phenotypically normal cells. The data suggest a constant chromosomal location of c-Ki-ras2.
Similar articles
- Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes.
Sakaguchi AY, Lalley PA, Zabel BU, Ellis RW, Scolnick EM, Naylor SL. Sakaguchi AY, et al. Proc Natl Acad Sci U S A. 1984 Jan;81(2):525-9. doi: 10.1073/pnas.81.2.525. Proc Natl Acad Sci U S A. 1984. PMID: 6320193 Free PMC article. - Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations.
Capon DJ, Seeburg PH, McGrath JP, Hayflick JS, Edman U, Levinson AD, Goeddel DV. Capon DJ, et al. Nature. 1983 Aug 11-17;304(5926):507-13. doi: 10.1038/304507a0. Nature. 1983. PMID: 6308467 - Oncogene from human EJ bladder carcinoma is located on the short arm of chromosome 11.
de Martinville B, Giacalone J, Shih C, Weinberg RA, Francke U. de Martinville B, et al. Science. 1983 Feb 4;219(4584):498-501. doi: 10.1126/science.6297001. Science. 1983. PMID: 6297001 - Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses.
Chang EH, Gonda MA, Ellis RW, Scolnick EM, Lowy DR. Chang EH, et al. Proc Natl Acad Sci U S A. 1982 Aug;79(16):4848-52. doi: 10.1073/pnas.79.16.4848. Proc Natl Acad Sci U S A. 1982. PMID: 6289320 Free PMC article. - Cellular transforming genes and oncogenesis.
Cooper GM, Lane MA. Cooper GM, et al. Biochim Biophys Acta. 1984;738(1-2):9-20. doi: 10.1016/0304-419x(84)90017-9. Biochim Biophys Acta. 1984. PMID: 6331501 Review. No abstract available.
Cited by
- 40 Years of RAS-A Historic Overview.
Fernández-Medarde A, De Las Rivas J, Santos E. Fernández-Medarde A, et al. Genes (Basel). 2021 May 1;12(5):681. doi: 10.3390/genes12050681. Genes (Basel). 2021. PMID: 34062774 Free PMC article. Review. - Regional chromosomal localization of N-ras, K-ras-1, K-ras-2 and myb oncogenes in human cells.
McBride OW, Swan DC, Tronick SR, Gol R, Klimanis D, Moore DE, Aaronson SA. McBride OW, et al. Nucleic Acids Res. 1983 Dec 10;11(23):8221-36. doi: 10.1093/nar/11.23.8221. Nucleic Acids Res. 1983. PMID: 6672765 Free PMC article. - Localisation of the human N-ras oncogene to chromosome 1cen - p21 by in situ hybridisation.
Davis M, Malcolm S, Hall A, Marshall CJ. Davis M, et al. EMBO J. 1983;2(12):2281-3. doi: 10.1002/j.1460-2075.1983.tb01735.x. EMBO J. 1983. PMID: 6667677 Free PMC article. - Oncogenic genes and human malignancy.
Lebowitz P. Lebowitz P. Yale J Biol Med. 1983 Mar-Apr;56(2):121-9. Yale J Biol Med. 1983. PMID: 6636835 Free PMC article. - The William Allan Memorial Award address: Reverse genetics and beyond.
Ruddle FH. Ruddle FH. Am J Hum Genet. 1984 Sep;36(5):944-53. Am J Hum Genet. 1984. PMID: 6594045 Free PMC article. No abstract available.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources