Segregation and linkage analyses in families of patients with bipolar, unipolar, and schizoaffective mood disorders - PubMed (original) (raw)

• PMID: 6837575
• PMCID: PMC1685536

Segregation and linkage analyses in families of patients with bipolar, unipolar, and schizoaffective mood disorders

L R Goldin et al. Am J Hum Genet. 1983 Mar.

Abstract

Hypotheses of single major locus transmission (autosomal and X chromosome) of major affective disorder (i.e., bipolar, unipolar, and schizoaffective) are tested using the Elston-Stewart likelihood method of pedigree segregation analysis. The sample consists of families of varying size ascertained through patients treated at the National Institute of Mental Health in Bethesda, Maryland. We test hypotheses on subsamples of families according to: (1) diagnosis of proband (75 bipolar I, 22 bipolar II, 18 unipolar, and six schizoaffective); (2) extreme value of a biological trait in the proband ("low" monoamine oxidase, "low" cerebrospinal fluid serotonin metabolite 5-HIAA); and (3) positive response to lithium in the proband. We cannot find evidence for single major locus transmission of major affective disorder from segregation analysis in any subsample of family even when the diagnostic classification of ill phenotypes is widened to include possible affective "spectrum" diagnoses. In addition, linkage studies of 21 autosomal markers do not provide evidence for single major locus transmission of illness. The maximum lod score, found for 30 families at the MNS locus, was 1.39 at 20% recombination.

PubMed Disclaimer

Similar articles

• A study of chromosome 4p markers and dopamine D5 receptor gene in schizophrenia and bipolar disorder.
  Asherson P, Mant R, Williams N, Cardno A, Jones L, Murphy K, Collier DA, Nanko S, Craddock N, Morris S, Muir W, Blackwood B, McGuffin P, Owen MJ. Asherson P, et al. Mol Psychiatry. 1998 Jul;3(4):310-20. doi: 10.1038/sj.mp.4000399. Mol Psychiatry. 1998. PMID: 9702739
• A locus for bipolar affective disorder on chromosome 4p.
  Blackwood DH, He L, Morris SW, McLean A, Whitton C, Thomson M, Walker MT, Woodburn K, Sharp CM, Wright AF, Shibasaki Y, St Clair DM, Porteous DJ, Muir WJ. Blackwood DH, et al. Nat Genet. 1996 Apr;12(4):427-30. doi: 10.1038/ng0496-427. Nat Genet. 1996. PMID: 8630499
• Segregation and linkage analyses of bipolar and major depressive illnesses in multigenerational pedigrees.
  Cox N, Reich T, Rice J, Elston R, Schober J, Keats B. Cox N, et al. J Psychiatr Res. 1989;23(2):109-23. doi: 10.1016/0022-3956(89)90002-2. J Psychiatr Res. 1989. PMID: 2585343
• Genetic transmission of major affective disorders: quantitative models and linkage analyses.
  Faraone SV, Kremen WS, Tsuang MT. Faraone SV, et al. Psychol Bull. 1990 Jul;108(1):109-27. doi: 10.1037/0033-2909.108.1.109. Psychol Bull. 1990. PMID: 2200070 Review.
• Reassessing the bipolar-unipolar dichotomy.
  Taylor MA, Abrams R. Taylor MA, et al. J Affect Disord. 1980 Sep;2(3):195-217. doi: 10.1016/0165-0327(80)90005-1. J Affect Disord. 1980. PMID: 6176608 Review.

Cited by

• Current perspectives on the genetics of unipolar depression.
  Moldin SO, Reich T, Rice JP. Moldin SO, et al. Behav Genet. 1991 May;21(3):211-42. doi: 10.1007/BF01065817. Behav Genet. 1991. PMID: 1863257 Review.
• Genetics of bipolar disorder.
  Craddock N, Jones I. Craddock N, et al. J Med Genet. 1999 Aug;36(8):585-94. doi: 10.1136/jmg.36.8.585. J Med Genet. 1999. PMID: 10465107 Free PMC article. Review.
• Toward a Deeper Understanding of the Genetics of Bipolar Disorder.
  Kerner B. Kerner B. Front Psychiatry. 2015 Aug 3;6:105. doi: 10.3389/fpsyt.2015.00105. eCollection 2015. Front Psychiatry. 2015. PMID: 26283973 Free PMC article. Review.
• Genetic segregation analysis of early-onset recurrent unipolar depression.
  Marazita ML, Neiswanger K, Cooper M, Zubenko GS, Giles DE, Frank E, Kupfer DJ, Kaplan BB. Marazita ML, et al. Am J Hum Genet. 1997 Dec;61(6):1370-8. doi: 10.1086/301627. Am J Hum Genet. 1997. PMID: 9399885 Free PMC article.
• Mathematical limits of multilocus models: the genetic transmission of bipolar disorder.
  Craddock N, Khodel V, Van Eerdewegh P, Reich T. Craddock N, et al. Am J Hum Genet. 1995 Sep;57(3):690-702. Am J Hum Genet. 1995. PMID: 7668299 Free PMC article.

References

1. 1. Compr Psychiatry. 1972 Jan;13(1):3-8 - PubMed
2. 1. Hum Hered. 1971;21(6):523-42 - PubMed
3. 1. JAMA. 1972 Dec 25;222(13):1624-7 - PubMed
4. 1. Am J Hum Genet. 1973 Sep;25(5):510-22 - PubMed
5. 1. Biol Psychiatry. 1973 Aug;7(1):63-74 - PubMed

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central

• Medical

  • MedlinePlus Health Information