Morphometric analysis of basal laminae in rats with long-term streptozotocin diabetes L. II. Retinal capillaries - PubMed (original) (raw)
Morphometric analysis of basal laminae in rats with long-term streptozotocin diabetes L. II. Retinal capillaries
F Fischer et al. Exp Eye Res. 1983 Jul.
Abstract
Twelve months after onset of streptozotocin-induced diabetes in rats, the basal lamina width of peripheral retinal capillaries, as measured with two different morphometric methods, is increased only in the basal lamina regions adjacent to perivascular glial cells. In the region between endothelial cells and pericytes no increase of thickness was observed. These facts support the suggestion of a predominantly glial (neuroectodermal) contribution to basal lamina thickening of retinal capillaries in diabetes mellitus. No correlation exists between the degree of basal lamina thickening at the different anatomic sites. Furthermore, no clear-cut correlation was found between basal lamina thickening and severity of the metabolic disease.
Similar articles
- Diabetic retinopathy: morphometric analysis of basement membrane thickening of capillaries in different retinal layers within arterial and venous environments.
Anderson HR, Stitt AW, Gardiner TA, Archer DB. Anderson HR, et al. Br J Ophthalmol. 1995 Dec;79(12):1120-3. doi: 10.1136/bjo.79.12.1120. Br J Ophthalmol. 1995. PMID: 8562548 Free PMC article. - [Electron microscopic observations on the retinal capillaries in streptozotocin-diabetic rat with special reference to the basal lamina of the capillary-(author's transl)].
Kojima K, Harada T, Miyake S, Sugita G. Kojima K, et al. Nippon Ganka Gakkai Zasshi. 1975 Mar 10;79(3):121-6. Nippon Ganka Gakkai Zasshi. 1975. PMID: 125532 Japanese. No abstract available. - Increased numbers of caveolae in retinal endothelium and pericytes in hypertensive diabetic rats.
Hillman N, Cox S, Noble AR, Gallagher PJ. Hillman N, et al. Eye (Lond). 2001 Jun;15(Pt 3):319-25. doi: 10.1038/eye.2001.103. Eye (Lond). 2001. PMID: 11450729 - Remodeling of retinal capillaries in the diabetic hypertensive rat.
Dosso AA, Leuenberger PM, Rungger-Brändle E. Dosso AA, et al. Invest Ophthalmol Vis Sci. 1999 Sep;40(10):2405-10. Invest Ophthalmol Vis Sci. 1999. PMID: 10476809 - Ultrastructural alterations during the development of retinopathy in sucrose-fed and streptozotocin-diabetic rats.
Papachristodoulou D, Heath H. Papachristodoulou D, et al. Exp Eye Res. 1977 Oct;25(4):371-84. doi: 10.1016/0014-4835(77)90104-x. Exp Eye Res. 1977. PMID: 590377 No abstract available.
Cited by
- Connective tissue growth factor is involved in structural retinal vascular changes in long-term experimental diabetes.
Van Geest RJ, Leeuwis JW, Dendooven A, Pfister F, Bosch K, Hoeben KA, Vogels IM, Van der Giezen DM, Dietrich N, Hammes HP, Goldschmeding R, Klaassen I, Van Noorden CJ, Schlingemann RO. Van Geest RJ, et al. J Histochem Cytochem. 2014 Feb;62(2):109-18. doi: 10.1369/0022155413512656. Epub 2013 Nov 11. J Histochem Cytochem. 2014. PMID: 24217924 Free PMC article. - Ultrastructural features of retinal capillary basement membrane thickening in diabetic swine.
Lee SE, Ma W, Rattigan EM, Aleshin A, Chen L, Johnson LL, D'Agati VD, Schmidt AM, Barile GR. Lee SE, et al. Ultrastruct Pathol. 2010 Feb;34(1):35-41. doi: 10.3109/01913120903308583. Ultrastruct Pathol. 2010. PMID: 20070152 Free PMC article. - Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice.
Kuiper EJ, van Zijderveld R, Roestenberg P, Lyons KM, Goldschmeding R, Klaassen I, Van Noorden CJ, Schlingemann RO. Kuiper EJ, et al. J Histochem Cytochem. 2008 Aug;56(8):785-92. doi: 10.1369/jhc.2008.950980. Epub 2008 May 12. J Histochem Cytochem. 2008. PMID: 18474939 Free PMC article. - Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats.
Stitt AW, Li YM, Gardiner TA, Bucala R, Archer DB, Vlassara H. Stitt AW, et al. Am J Pathol. 1997 Feb;150(2):523-31. Am J Pathol. 1997. PMID: 9033268 Free PMC article. - Diabetic retinopathy: morphometric analysis of basement membrane thickening of capillaries in different retinal layers within arterial and venous environments.
Anderson HR, Stitt AW, Gardiner TA, Archer DB. Anderson HR, et al. Br J Ophthalmol. 1995 Dec;79(12):1120-3. doi: 10.1136/bjo.79.12.1120. Br J Ophthalmol. 1995. PMID: 8562548 Free PMC article.