[Genetic characteristics of a new phage resistance trait in Streptomyces coelicolor A3(2)] - PubMed (original) (raw)

. 1982 Dec;18(12):1945-52.

[Article in Russian]

• PMID: 6891357

[Genetic characteristics of a new phage resistance trait in Streptomyces coelicolor A3(2)]

[Article in Russian]

T A Chinenova et al. Genetika. 1982 Dec.

Abstract

Phage resistance was investigated in the system of Streptomyces coelicolor A3(2) and phi C31 actinophage. Resistance of A3(2) strain to phi C31 was shown to involve a novel mechanism responsible for the arrest of phage intracellular growth in the whole cell population. The phage resistance character designated Pgl+ (for "phage growth limiting") is determined by a gene located on the A3(2) chromosome. The gene (pgl) controls phage "modification" which results in an inability of phage to lyse lysogenize Pgl+ host. Instability of the Pgl+ character was revealed. Pgl+ strains segregate Pgl variants at a high frequency, the majority of Pgl strains reverting to the initial Pgl+ phenotype with the same high frequency. Reversible Pgl+ in equilibrium Pgl transitions are a common feature of A3(2) cell population.

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