A new mouse tumor model system (RIF-1) for comparison of end-point studies - PubMed (original) (raw)

Comparative Study

. 1980 Mar;64(3):595-604.

Comparative Study

A new mouse tumor model system (RIF-1) for comparison of end-point studies

P R Twentyman et al. J Natl Cancer Inst. 1980 Mar.

Abstract

A new tumor model system (RIF-1) was developed that is very suitable for studies in which clonogenic survival is compared with growth delay and control probability following various forms of treatment. The tumor was a radiation-induced sarcoma in the inbred female C3H/Km mouse. It had a low median tumor dose, had a satisfactory plating efficiency direct from in vivo to in vitro, was nonimmunogenic or minimally immunogenic, and metastasized only at a relatively advanced stage of growth. The cell line grew either as a monolayer on plastic dishes, as tumor spheroids in spinner culture, as lung nodules following injection of a single-cell suspension into the tail veins of syngeneic mice, or as a solid tumor. Both diploid and tetraploid clonogenic cells were found in monolayer cultures of the RIF-1 line.

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