Two human c-onc genes are located on the long arm of chromosome 8 - PubMed (original) (raw)

Two human c-onc genes are located on the long arm of chromosome 8

B G Neel et al. Proc Natl Acad Sci U S A. 1982 Dec.

Abstract

We have used in situ chromosome hybridization techniques to map the human cellular counterparts (c-onc genes) of the transforming genes of two RNA tumor viruses on human meiotic pachytene and somatic metaphase chromosomes. We find that the human c-mos gene is located on chromosome 8 at a position corresponding to band 8q22 on the somatic map. The human c-myc gene is found on chromosome 8 at position 8q24. These regions on the long arm of chromosome 8 have been previously reported to be involved in specific translocations found in the M-2 subset of acute nonlymphoblastic leukemias. Burkitt lymphoma, and other forms of non-Hodgkin lymphoma, and a familial abnormality that predisposes to renal cell carcinoma. These results suggest that translocations of the human c-mos or c-myc genes may be causally related to neoplastic transformation.

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References

    1. Nature. 1972 May 5;237(5349):33-4 - PubMed
    1. Ann Genet. 1973 Jun;16(2):109-12 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Mar;72(3):1184-8 - PubMed
    1. Int J Cancer. 1976 Jan 15;17(1):47-56 - PubMed
    1. Cytogenet Cell Genet. 1978;21(4):231-40 - PubMed

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