Rat major histocompatibility RT1.C antigens of restricted tissue distribution consist of two polypeptide chains with molecular weights of about 42 000 and 12 500 - PubMed (original) (raw)

Comparative Study

Rat major histocompatibility RT1.C antigens of restricted tissue distribution consist of two polypeptide chains with molecular weights of about 42 000 and 12 500

D Haustein et al. Immunogenetics. 1982 Mar.

Abstract

The RT1.C region has recently been defined genetically as a third region of the rat major histocompatibility system, RT1, and has been shown to code for cell-surface antigens with restricted tissue distribution (present on lymphocytes and absent from red blood cells and liver) and for target antigens of unrestricted cytotoxic T lymphocytes. Immunoprecipitation with C-antigen-specific alloantisera and SDS-PAGE analysis, reveal that C-region products are glycoproteins composed of molecules of 40 500-43 000 and 12 500 molecular weight, respectively. Thus, the RT1.B region, which codes for class II molecules, is flanked by RT1 regions which determine class I molecules (as defined biochemically), which are either expressed ubiquitously (RT1.A antigens) or in a restricted manner (RT1.C products). The homology to H-2Qa antigens is discussed.

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