Selective localization and growth of Bifidobacterium bifidum in mouse tumors following intravenous administration - PubMed (original) (raw)
- PMID: 6989495
Selective localization and growth of Bifidobacterium bifidum in mouse tumors following intravenous administration
N T Kimura et al. Cancer Res. 1980 Jun.
Abstract
A strain of domestic bacteria, Bifidobacterium bifidum (Lac B), which is nonpathogenic and anerobic, selectively localized and proliferated in several types of mouse tumors following i.v. administration. None of the same bacilli could be detected in the tissues of healthy organs such as the liver, spleen, kidney, lung, blood, bone marrow, and muscle 48 or 96 hr after i.v. administration into tumor-bearing mice. Proliferation of Lac B in the tumor was artifically stimulated by i.p. administration of DDD-H-2s mice of a synthesized disaccharide, lactulose (4-O-beta-D-galactopyranosyl-D-fructofuranose), a sugar which is not metabolized by mammalian tissue cells. Lac B, which survices and proliferates selectively in the tumor following i.v. administration into the tumor-bearing host, should aid in diagnosis and selective therapy for cancer.
Similar articles
- Bifidobacterium longum as a delivery system for cancer gene therapy: selective localization and growth in hypoxic tumors.
Yazawa K, Fujimori M, Amano J, Kano Y, Taniguchi S. Yazawa K, et al. Cancer Gene Ther. 2000 Feb;7(2):269-74. doi: 10.1038/sj.cgt.7700122. Cancer Gene Ther. 2000. PMID: 10770636 - Purine nucleotide levels in host tissues of Ehrlich ascites tumor-bearing mice in different growth phases of the tumor.
Siems WG, Grune T, Schmidt H, Tikhonov YV, Pimenov AM. Siems WG, et al. Cancer Res. 1993 Nov 1;53(21):5143-7. Cancer Res. 1993. PMID: 8221650 - cis-Amminedichloro(2-methylpyridine) platinum(II) (AMD473), a novel sterically hindered platinum complex: in vivo activity, toxicology, and pharmacokinetics in mice.
Raynaud FI, Boxall FE, Goddard PM, Valenti M, Jones M, Murrer BA, Abrams M, Kelland LR. Raynaud FI, et al. Clin Cancer Res. 1997 Nov;3(11):2063-74. Clin Cancer Res. 1997. PMID: 9815598
Cited by
- Intratumoral Microbiome: Foe or Friend in Reshaping the Tumor Microenvironment Landscape?
Kyriazi AA, Karaglani M, Agelaki S, Baritaki S. Kyriazi AA, et al. Cells. 2024 Jul 30;13(15):1279. doi: 10.3390/cells13151279. Cells. 2024. PMID: 39120310 Free PMC article. Review. - Promising dawn in tumor microenvironment therapy: engineering oral bacteria.
Wang Z, Sun W, Hua R, Wang Y, Li Y, Zhang H. Wang Z, et al. Int J Oral Sci. 2024 Mar 13;16(1):24. doi: 10.1038/s41368-024-00282-3. Int J Oral Sci. 2024. PMID: 38472176 Free PMC article. Review. - Tumor-homing bacterium-adsorbed liposomes encapsulating perfluorohexane/doxorubicin enhance pulsed-focused ultrasound for tumor therapy.
Ou X, Zhang Z, Lin L, Du Y, Tang Y, Wang Y, Zou J. Ou X, et al. RSC Adv. 2023 Jun 23;13(28):19065-19078. doi: 10.1039/d3ra01876h. eCollection 2023 Jun 22. RSC Adv. 2023. PMID: 37362333 Free PMC article. - Nanomedicines for high‑intensity focused ultrasound cancer treatment and theranostics (Review).
Zheng Q, Xia B, Huang X, Luo J, Zhong S, Li X. Zheng Q, et al. Exp Ther Med. 2023 Mar 3;25(4):170. doi: 10.3892/etm.2023.11869. eCollection 2023 Apr. Exp Ther Med. 2023. PMID: 37006877 Free PMC article. Review. - Blautia coccoides JCM1395T Achieved Intratumoral Growth with Minimal Inflammation: Evidence for Live Bacterial Therapeutic Potential by an Optimized Sample Preparation and Colony PCR Method.
Nomura S, Sukowati EW, Shigeno Y, Takahashi M, Kato A, Benno Y, Yamashita F, Mukai H. Nomura S, et al. Pharmaceutics. 2023 Mar 19;15(3):989. doi: 10.3390/pharmaceutics15030989. Pharmaceutics. 2023. PMID: 36986850 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials