Immunosuppressive properties of polar organic compounds that induce cellular differentiation in Friend erythroleukemia cells - PubMed (original) (raw)

Immunosuppressive properties of polar organic compounds that induce cellular differentiation in Friend erythroleukemia cells

M Suthanthiran et al. Transplantation. 1982 May.

Abstract

We studied the effect of several polar organic compounds, known to induce erythroid differentiation in Friend leukemia (FL) cells, on in vitro human lymphocyte responses and on skin graft survival in mice. The short chain fatty acids, butyric acid (BA), propionic acid (PA), valeric acid, and the polar organic solvents, dimethyl sulfoxide, dimethylformamide, and dimethylacetamide, all mediated significant inhibition of alloantigen-induced proliferation and generation of cytotoxic T lymphocytes (CTLs) in human primary and secondary mixed lymphocyte culture (MLC) reactions. Hexamethylenebisacetemide, another potent inducer of differentiation in FL cells, also mediated significant suppression. Inhibition of MLC with polar organic compounds was accomplished at concentrations known to induce differentiation in FL cells and that are not cytotoxic to peripheral blood mononuclear cells. In distinct contrast, agents that are structurally related to BA, but that do not induce differentiation in FL cells, such as caproic acid, beta-OHBA, gamma-amino BA, and isobutyric acid, did not exhibit immunosuppressive properties. Pokeweed mitogen-driven polyclonal B cell activation was also suppressed by agents that induce erythroid differentiation in FL cells. In addition to potent in vitro immunosuppressive properties, supplementation of drinking water with BA or PA resulted in prolongation of full-thickness skin grafts in DBA/2 (H-2d) to C57BL/6 (H-2b) donor-recipient combinations. Our findings indicate that polar organic compounds that induce differentiation in FL cells are potent immunosuppressive agents.

PubMed Disclaimer

Similar articles

• A new class of inhibitors of lymphocyte mitogenesis: agents that induce erythroid differentiation in Friend leukemia cells.
  Novogrodsky A, Rubin AL, Stenzel KH. Novogrodsky A, et al. J Immunol. 1980 Apr;124(4):1892-7. J Immunol. 1980. PMID: 7189200
• Chemical inducers of differentiation in Friend leukaemia cells inhibit lymphocyte mitogenesis.
  Stenzel KH, Schwartz R, Rubin AL, Novogrodsky A. Stenzel KH, et al. Nature. 1980 May 8;285(5760):106-8. doi: 10.1038/285106a0. Nature. 1980. PMID: 7374756
• Induction and properties of beta-adrenergic receptors during erythroid differentiation of Friend leukemic cells.
  Schmitt H, Guyaux M, Pochet R, Kram R. Schmitt H, et al. Proc Natl Acad Sci U S A. 1980 Jul;77(7):4065-8. doi: 10.1073/pnas.77.7.4065. Proc Natl Acad Sci U S A. 1980. PMID: 6254010 Free PMC article.
• Genetic resistance to Friend virus-induced erythroleukemia and immunosuppression.
  Kumar V, Bennett M. Kumar V, et al. Curr Top Microbiol Immunol. 1981;92:65-82. doi: 10.1007/978-3-642-68069-4_5. Curr Top Microbiol Immunol. 1981. PMID: 6458455 Review. No abstract available.
• Alkylformamides as inducers of tumour cell differentiation--a mini-review.
  Langdon SP, Hickman JA. Langdon SP, et al. Toxicology. 1987 Mar;43(3):239-49. doi: 10.1016/0300-483x(87)90083-7. Toxicology. 1987. PMID: 3547773 Review.

Cited by

• Propionic acid regulates immune tolerant properties in B Cells.
  Tian GX, Peng KP, Yu Y, Liang CB, Xie HQ, Guo YY, Zhou S, Zheng MBW, Zheng PY, Yang PC. Tian GX, et al. J Cell Mol Med. 2022 May;26(10):2766-2776. doi: 10.1111/jcmm.17287. Epub 2022 Mar 27. J Cell Mol Med. 2022. PMID: 35343043 Free PMC article.
• Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice.
  Reddy P, Sun Y, Toubai T, Duran-Struuck R, Clouthier SG, Weisiger E, Maeda Y, Tawara I, Krijanovski O, Gatza E, Liu C, Malter C, Mascagni P, Dinarello CA, Ferrara JL. Reddy P, et al. J Clin Invest. 2008 Jul;118(7):2562-73. doi: 10.1172/JCI34712. J Clin Invest. 2008. PMID: 18568076 Free PMC article.
• Butyrate affects differentiation, maturation and function of human monocyte-derived dendritic cells and macrophages.
  Millard AL, Mertes PM, Ittelet D, Villard F, Jeannesson P, Bernard J. Millard AL, et al. Clin Exp Immunol. 2002 Nov;130(2):245-55. doi: 10.1046/j.0009-9104.2002.01977.x. Clin Exp Immunol. 2002. PMID: 12390312 Free PMC article.
• n-butyrate downregulates the stimulatory function of peripheral blood-derived antigen-presenting cells: a potential mechanism for modulating T-cell responses by short-chain fatty acids.
  Böhmig GA, Krieger PM, Säemann MD, Wenhardt C, Pohanka E, Zlabinger GJ. Böhmig GA, et al. Immunology. 1997 Oct;92(2):234-43. doi: 10.1046/j.1365-2567.1997.00337.x. Immunology. 1997. PMID: 9415032 Free PMC article.
• Inhibition of human lymphocyte function by organic solvents.
  Shoker AS, Murabit MA, Georges FF, Qualtiere LF, Deneer HG, Prasad K. Shoker AS, et al. Mol Cell Biochem. 1997 Jun;171(1-2):49-58. doi: 10.1023/a:1006882114285. Mol Cell Biochem. 1997. PMID: 9201695

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database