Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma - PubMed (original) (raw)

Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma

J J Yunis et al. N Engl J Med. 1982.

Abstract

Using a new high-resolution technique for chromosomal analysis, we have successfully studied biopsy specimens of lymph nodes from 42 of 44 patients with non-Hodgkin's lymphoma and have categorized them using the new international histologic formulation and immunologic markers. Abnormalities of the clonal chromosomes were detected in all 42 patients. Three recurrent chromosomal aberrations were found to correlate with certain histologic types: a translocation between chromosomes 18 and 14 in 16 of 19 patients with follicular lymphomas (small cleaved cell, mixed cell, and large cell); a translocation between chromosomes 8 and 14 in 5 of 6 patients with small noncleaved-cell (non-Burkitt's) or large-cell immunoblastic lymphoma; and a trisomy 12 in 4 of 11 patients with small-cell lymphocytic lymphoma. Our findings suggest that characteristic chromosomal defects occur in certain lymphoma subtypes and that high-resolution chromosomal analysis promises to become an important tool in improving our basic understanding of lymphoid cancers.

PubMed Disclaimer

Similar articles

• Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer.
  Yunis JJ, Frizzera G, Oken MM, McKenna J, Theologides A, Arnesen M. Yunis JJ, et al. N Engl J Med. 1987 Jan 8;316(2):79-84. doi: 10.1056/NEJM198701083160204. N Engl J Med. 1987. PMID: 3537802
• [Cytogenetic results in 9 cases of non-Hodgkin's lymphoma with a high grade of malignancy].
  López Ginés C, Gil R, Gregori-Romero M, Pellín A, Llombart-Bosch A. López Ginés C, et al. Sangre (Barc). 1989 Aug;34(4):278-84. Sangre (Barc). 1989. PMID: 2772781 Spanish.
• Chromosomal abnormalities and molecular genetics of non-Hodgkin's lymphoma.
  Ong ST, Le Beau MM. Ong ST, et al. Semin Oncol. 1998 Aug;25(4):447-60. Semin Oncol. 1998. PMID: 9728595 Review.
• [Chromosomal abnormalities in cells of lymph node in two patients with IBL-like T-cell lymphoma].
  Sadamori N, Itoyama T, Sasagawa I, Nakamura H, Soda H, Ikeda S, Ichimaru M, Kusano M, Tagawa M, Jubashi T. Sadamori N, et al. Rinsho Ketsueki. 1988 Jul;29(7):1109-14. Rinsho Ketsueki. 1988. PMID: 3054203 Review. Japanese. No abstract available.

Cited by

• Chronic lymphocytic leukemia with t(14;18)(q32;q21).
  Tang G, Banks HE, Sargent RL, Medeiros LJ, Abruzzo LV. Tang G, et al. Hum Pathol. 2013 Apr;44(4):598-605. doi: 10.1016/j.humpath.2012.07.005. Epub 2012 Oct 16. Hum Pathol. 2013. PMID: 23084581 Free PMC article.
• Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice.
  Masle-Farquhar E, Russell A, Li Y, Zhu F, Rui L, Brink R, Goodnow CC. Masle-Farquhar E, et al. PLoS One. 2021 Apr 29;16(4):e0237830. doi: 10.1371/journal.pone.0237830. eCollection 2021. PLoS One. 2021. PMID: 33914737 Free PMC article.
• Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.
  Bakhshi A, Wright JJ, Graninger W, Seto M, Owens J, Cossman J, Jensen JP, Goldman P, Korsmeyer SJ. Bakhshi A, et al. Proc Natl Acad Sci U S A. 1987 Apr;84(8):2396-400. doi: 10.1073/pnas.84.8.2396. Proc Natl Acad Sci U S A. 1987. PMID: 3104914 Free PMC article.
• The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation.
  Chen-Levy Z, Nourse J, Cleary ML. Chen-Levy Z, et al. Mol Cell Biol. 1989 Feb;9(2):701-10. doi: 10.1128/mcb.9.2.701-710.1989. Mol Cell Biol. 1989. PMID: 2651903 Free PMC article.
• Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation.
  Kasai M, Maziarz RT, Aoki K, Macintyre E, Strominger JL. Kasai M, et al. Mol Cell Biol. 1992 Oct;12(10):4751-7. doi: 10.1128/mcb.12.10.4751-4757.1992. Mol Cell Biol. 1992. PMID: 1406658 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • The Weizmann Institute of Science GeneCards and MalaCards databases