Dexamethasone suppression test and cortisol circadian rhythm in primary degenerative dementia - PubMed (original) (raw)
Dexamethasone suppression test and cortisol circadian rhythm in primary degenerative dementia
M Raskind et al. Am J Psychiatry. 1982 Nov.
Abstract
Before the dexamethasone suppression test (DST) can be accepted as a valid diagnostic tool for differentiating depression from dementia, it must be demonstrated that dementing illnesses per se are not associated with a positive DST. The authors studied cortisol circadian rhythm and the overnight DST in 15 nondepressed patients with advanced primary degenerative dementia and 15 normal control subjects. Seven dementia patients and no control patients were DST positive. The DST-positive dementia patients had a blunted predexamethasone circadian cortisol rhythm. These results cast doubt on the utility of the DST in diagnosing depression that complicates advanced primary degenerative dementia.
Similar articles
- The dexamethasone suppression test in dementia: a review of the literature.
Skare S, Pew B, Dysken M. Skare S, et al. J Geriatr Psychiatry Neurol. 1990 Jul-Sep;3(3):124-38. doi: 10.1177/089198879000300302. J Geriatr Psychiatry Neurol. 1990. PMID: 2282129 Review. - Dexamethasone suppression in dementia, depression, and normal aging.
Georgotas A, McCue RE, Kim OM, Hapworth WE, Reisberg B, Stoll PM, Sinaiko E, Fanelli C, Stokes PE. Georgotas A, et al. Am J Psychiatry. 1986 Apr;143(4):452-6. doi: 10.1176/ajp.143.4.452. Am J Psychiatry. 1986. PMID: 3953888 - The dexamethasone suppression index: enhancement of DST diagnostic utility for depression by expressing serum cortisol as a function of serum dexamethasone.
Arana GW, Reichlin S, Workman R, Haaser R, Shader RI. Arana GW, et al. Am J Psychiatry. 1988 Jun;145(6):707-11. doi: 10.1176/ajp.145.6.707. Am J Psychiatry. 1988. PMID: 3369557 - Use of the dexamethasone suppression test with depressed and demented elderly.
Gierl B, Groves L, Lazarus LW. Gierl B, et al. J Am Geriatr Soc. 1987 Feb;35(2):115-20. doi: 10.1111/j.1532-5415.1987.tb01339.x. J Am Geriatr Soc. 1987. PMID: 3805553 - The dexamethasone suppression test: an overview of its current status in psychiatry. The APA Task Force on Laboratory Tests in Psychiatry.
[No authors listed] [No authors listed] Am J Psychiatry. 1987 Oct;144(10):1253-62. doi: 10.1176/ajp.144.10.1253. Am J Psychiatry. 1987. PMID: 3310667 Review.
Cited by
- ACTH and cortisol secretion in patients with Alzheimer's disease.
Franceschi M, Airaghi L, Gramigna C, Truci G, Manfredi MG, Canal N, Catania A. Franceschi M, et al. J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):836-7. doi: 10.1136/jnnp.54.9.836. J Neurol Neurosurg Psychiatry. 1991. PMID: 1659618 Free PMC article. - Glucocorticoid Resistance: Is It a Requisite for Increased Cytokine Production in Depression? A Systematic Review and Meta-Analysis.
Perrin AJ, Horowitz MA, Roelofs J, Zunszain PA, Pariante CM. Perrin AJ, et al. Front Psychiatry. 2019 Jun 28;10:423. doi: 10.3389/fpsyt.2019.00423. eCollection 2019. Front Psychiatry. 2019. PMID: 31316402 Free PMC article. - Dexamethasone effects on cortisol secretion in Alzheimer's disease: some clinical and hormonal features in suppressor and nonsuppressor patients.
Murialdo G, Barreca A, Nobili F, Rollero A, Timossi G, Gianelli MV, Copello F, Rodriguez G, Polleri A. Murialdo G, et al. J Endocrinol Invest. 2000 Mar;23(3):178-86. doi: 10.1007/BF03343703. J Endocrinol Invest. 2000. PMID: 10803476 Clinical Trial. - What is the evidence to support the use of therapeutic gardens for the elderly?
Detweiler MB, Sharma T, Detweiler JG, Murphy PF, Lane S, Carman J, Chudhary AS, Halling MH, Kim KY. Detweiler MB, et al. Psychiatry Investig. 2012 Jun;9(2):100-10. doi: 10.4306/pi.2012.9.2.100. Epub 2012 May 22. Psychiatry Investig. 2012. PMID: 22707959 Free PMC article. - Alzheimer's disease: pathophysiological implications of measurement of plasma cortisol, plasma dehydroepiandrosterone sulfate, and lymphocytic corticosteroid receptors.
Armanini D, Vecchio F, Basso A, Milone FF, Simoncini M, Fiore C, Mattarello MJ, Sartorato P, Karbowiak I. Armanini D, et al. Endocrine. 2003 Nov;22(2):113-8. doi: 10.1385/ENDO:22:2:113. Endocrine. 2003. PMID: 14665714
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous