Glial fibrillary acidic protein and Alzheimer-type senile dementia - PubMed (original) (raw)
Glial fibrillary acidic protein and Alzheimer-type senile dementia
P E Duffy et al. Neurology. 1980 Jul.
Abstract
Glial fibrillary acidic protein (GFAP), a protein that is associated with 9-nm filaments of astrocytes, was observed to be increased in the astrocytes surrounding senile plaques in patients with Alzheimer dementia and in aged subjects without dementia. A few GFAP-positive fibers were seen in the centers of plaques. These results emphasized the selectivity of senile changes; whereas some cells seemed to undergo degeneration or dysfunction, other cells--astrocytes--maintain their capacity for reaction and may increase the formation of at least one protein, GFAP.
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