Genetic organization of the region around UNC-15 (I), a gene affecting paramyosin in Caenorhabditis elegans - PubMed (original) (raw)
Genetic organization of the region around UNC-15 (I), a gene affecting paramyosin in Caenorhabditis elegans
A M Rose et al. Genetics. 1980 Nov.
Abstract
In the nematode Caenorhabditis elegans mutants in the gene unc-15 (I) affect the muscle protein paramyosin (Waterston, Fishpool and Brenner 1977). We have characterized 20 ethyl methanesulfonate-induced mutations in essential genes closely linked to unc-15. These lethals defined 16 new complementation groups. In the 0.65 map-unit interval around unc-15 defined by dpy-14 and unc-56, seven newly identified genes have been mapped relative to five existing genes. At present, the average distance between genes in this region is approximately 0.05 map units. Two genes, unc-15 and unc-13, are only 0.025 map units apart. Partial fine-structures maps of alleles of these two genes have been constructed. This analysis of unc-15 and genes adjacent to it is the first in a series of genetic and biochemical studies directed towards understanding the control of unc-15 expression.
Similar articles
- Genetic organization of the unc-60 region in Caenorhabditis elegans.
McKim KS, Heschl MF, Rosenbluth RE, Baillie DL. McKim KS, et al. Genetics. 1988 Jan;118(1):49-59. doi: 10.1093/genetics/118.1.49. Genetics. 1988. PMID: 8608931 Free PMC article. - Essential genes and deficiencies in the unc-22 IV region of Caenorhabditis elegans.
Rogalski TM, Moerman DG, Baillie DL. Rogalski TM, et al. Genetics. 1982 Dec;102(4):725-36. doi: 10.1093/genetics/102.4.725. Genetics. 1982. PMID: 7187364 Free PMC article. - The unc-22(IV) region of Caenorhabditis elegans: genetic analysis of lethal mutations.
Clark DV, Rogalski TM, Donati LM, Baillie DL. Clark DV, et al. Genetics. 1988 Jun;119(2):345-53. doi: 10.1093/genetics/119.2.345. Genetics. 1988. PMID: 3396868 Free PMC article. - Genetic analysis of myosin assembly in Caenorhabditis elegans.
Epstein HF. Epstein HF. Mol Neurobiol. 1990 Spring-Summer;4(1-2):1-25. doi: 10.1007/BF02935583. Mol Neurobiol. 1990. PMID: 2076218 Review. - Beyond induced mutants: using worms to study natural variation in genetic pathways.
Kammenga JE, Phillips PC, De Bono M, Doroszuk A. Kammenga JE, et al. Trends Genet. 2008 Apr;24(4):178-85. doi: 10.1016/j.tig.2008.01.001. Epub 2008 Mar 5. Trends Genet. 2008. PMID: 18325626 Review.
Cited by
- Muscle-directed mechanosensory feedback activates egg-laying circuit activity and behavior in Caenorhabditis elegans.
Medrano E, Collins KM. Medrano E, et al. Curr Biol. 2023 Jun 5;33(11):2330-2339.e8. doi: 10.1016/j.cub.2023.05.008. Epub 2023 May 25. Curr Biol. 2023. PMID: 37236183 Free PMC article. - Serotonin signals through postsynaptic Gαq, Trio RhoGEF, and diacylglycerol to promote Caenorhabditis elegans egg-laying circuit activity and behavior.
Dhakal P, Chaudhry SI, Signorelli R, Collins KM. Dhakal P, et al. Genetics. 2022 Jul 4;221(3):iyac084. doi: 10.1093/genetics/iyac084. Genetics. 2022. PMID: 35579369 Free PMC article. - Identification of Suppressors of top-2 Embryonic Lethality in Caenorhabditis elegans.
Bhandari N, Rourke C, Wilmoth T, Bheemreddy A, Schulman D, Collins D, Smith HE, Golden A, Jaramillo-Lambert A. Bhandari N, et al. G3 (Bethesda). 2020 Apr 9;10(4):1183-1191. doi: 10.1534/g3.119.400927. G3 (Bethesda). 2020. PMID: 32086248 Free PMC article. - Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.
Yang X, Wang S, Sheng Y, Zhang M, Zou W, Wu L, Kang L, Rizo J, Zhang R, Xu T, Ma C. Yang X, et al. Nat Struct Mol Biol. 2015 Jul;22(7):547-54. doi: 10.1038/nsmb.3038. Epub 2015 Jun 1. Nat Struct Mol Biol. 2015. PMID: 26030875 Free PMC article. - Rapid and Efficient Identification of Caenorhabditis elegans Legacy Mutations Using Hawaiian SNP-Based Mapping and Whole-Genome Sequencing.
Jaramillo-Lambert A, Fuchsman AS, Fabritius AS, Smith HE, Golden A. Jaramillo-Lambert A, et al. G3 (Bethesda). 2015 Mar 4;5(5):1007-19. doi: 10.1534/g3.115.017038. G3 (Bethesda). 2015. PMID: 25740937 Free PMC article.
References
- Genetics. 1974 May;77(1):71-94 - PubMed
- J Mol Biol. 1977 Dec 15;117(3):679-97 - PubMed
- Nature. 1978 Oct 26;275(5682):715-9 - PubMed
- Nature. 1979 May 10;279(5709):125-32 - PubMed
- Genetics. 1979 May;92(1):133-49 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources