Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil: The Gastrointestinal Tumor Study Group - PubMed (original) (raw)

Clinical Trial

. 1981 Oct 15;48(8):1705-10.

doi: 10.1002/1097-0142(19811015)48:8<1705::aid-cncr2820480803>3.0.co;2-4.

S Frytak, R G Hahn, M J O'Connell, R J Reitemeier, J Rubin, A J Schutt, L H Weiland, D S Childs, M A Holbrook, P T Lavin, E Livstone, H Spiro, A Knowlton, M Kalser, J Barkin, H Lessner, R Mann-Kaplan, K Ramming, H O Douglas Jr, P Thomas, H Nave, J Bateman, J Lokich, J Brooks, J Chaffey, J M Corson, N Zamcheck, J W Novak

Clinical Trial

Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil: The Gastrointestinal Tumor Study Group

C G Moertel et al. Cancer. 1981.

Abstract

One-hundred-ninety-four eligible and evaluable patients with histologically confirmed locally unresectable adenocarcinoma of the pancreas were randomly assigned to therapy with high-dose (6000 rads) radiation therapy alone, to moderate-dose (4000 rads) radiation + 5-fluorouracil (5-FU), and to high-dose radiation plus 5-FU. Median survival with radiation alone was only 51/2 months from date of diagnosis. Both 5-FU-containing treatment regimens produced a highly significant survival improvement when compared with radiation alone. Forty percent of patients treated with the combined regimens were still living at one year compared with 10% of patients treated with radiation only. Survival differences between 4000 rads plus 5-FU and 6000 rads plus 5-FU were not significant with an overall median survival of ten months. Significant prognostic variables, in addition to treatment, were pretreatment performance status and pretreatment CEA level.

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