Oversized flagellar membrane protein in paralyzed mutants of Chlamydomonas reinhardrii - PubMed (original) (raw)
Oversized flagellar membrane protein in paralyzed mutants of Chlamydomonas reinhardrii
J W Jarvik et al. J Cell Biol. 1980 May.
Abstract
A mutant strain of Chlamydomonas reinhardtii is shown to possess an oversized flagellar membrane protein. The mutant has paralyzed flagella, is temperature sensitive for flagellar assembly, and has an abnormal axonemal protein composition. All phenotypes appear to derive from a single Mendelian mutation, and genetic analysis suggests that the mutation, which call ts222, is in the gene pfl. Because pf1 mutants are known to have radial-spoke defects (Piperno et al., 1977, Proc. Natl. Acad. Sci. U. S. A. 74:1600-1604; and Witman et al., 1978, J. Cell Biol. 76:729-797), a relation as yet undefined appears to exist between radial-spoke and flagellar membrane biogenesis.
Similar articles
- Molecular cloning and sequence analysis of the Chlamydomonas gene coding for radial spoke protein 3: flagellar mutation pf-14 is an ochre allele.
Williams BD, Velleca MA, Curry AM, Rosenbaum JL. Williams BD, et al. J Cell Biol. 1989 Jul;109(1):235-45. doi: 10.1083/jcb.109.1.235. J Cell Biol. 1989. PMID: 2745550 Free PMC article. - Flagellar mutants of Chlamydomonas: studies of radial spoke-defective strains by dikaryon and revertant analysis.
Luck D, Piperno G, Ramanis Z, Huang B. Luck D, et al. Proc Natl Acad Sci U S A. 1977 Aug;74(8):3456-60. doi: 10.1073/pnas.74.8.3456. Proc Natl Acad Sci U S A. 1977. PMID: 269405 Free PMC article. - Rescue of a paralyzed-flagella mutant of Chlamydomonas by transformation.
Diener DR, Curry AM, Johnson KA, Williams BD, Lefebvre PA, Kindle KL, Rosenbaum JL. Diener DR, et al. Proc Natl Acad Sci U S A. 1990 Aug;87(15):5739-43. doi: 10.1073/pnas.87.15.5739. Proc Natl Acad Sci U S A. 1990. PMID: 2377611 Free PMC article. - Flagellar radial spoke: a model molecular genetic system for studying organelle assembly.
Curry AM, Rosenbaum JL. Curry AM, et al. Cell Motil Cytoskeleton. 1993;24(4):224-32. doi: 10.1002/cm.970240403. Cell Motil Cytoskeleton. 1993. PMID: 8477455 Review. No abstract available. - Exploring the function of inner and outer dynein arms with Chlamydomonas mutants.
Kamiya R. Kamiya R. Cell Motil Cytoskeleton. 1995;32(2):98-102. doi: 10.1002/cm.970320205. Cell Motil Cytoskeleton. 1995. PMID: 8681402 Review.
Cited by
- Mutations in PIH proteins MOT48, TWI1 and PF13 define common and unique steps for preassembly of each, different ciliary dynein.
Yamamoto R, Yanagi S, Nagao M, Yamasaki Y, Tanaka Y, Sale WS, Yagi T, Kon T. Yamamoto R, et al. PLoS Genet. 2020 Nov 3;16(11):e1009126. doi: 10.1371/journal.pgen.1009126. eCollection 2020 Nov. PLoS Genet. 2020. PMID: 33141819 Free PMC article. - The Developmental Process of the Growing Motile Ciliary Tip Region.
Reynolds MJ, Phetruen T, Fisher RL, Chen K, Pentecost BT, Gomez G, Ounjai P, Sui H. Reynolds MJ, et al. Sci Rep. 2018 May 22;8(1):7977. doi: 10.1038/s41598-018-26111-2. Sci Rep. 2018. PMID: 29789632 Free PMC article. - Chlamydomonas DYX1C1/PF23 is essential for axonemal assembly and proper morphology of inner dynein arms.
Yamamoto R, Obbineni JM, Alford LM, Ide T, Owa M, Hwang J, Kon T, Inaba K, James N, King SM, Ishikawa T, Sale WS, Dutcher SK. Yamamoto R, et al. PLoS Genet. 2017 Sep 11;13(9):e1006996. doi: 10.1371/journal.pgen.1006996. eCollection 2017 Sep. PLoS Genet. 2017. PMID: 28892495 Free PMC article. - An Indexed, Mapped Mutant Library Enables Reverse Genetics Studies of Biological Processes in Chlamydomonas reinhardtii.
Li X, Zhang R, Patena W, Gang SS, Blum SR, Ivanova N, Yue R, Robertson JM, Lefebvre PA, Fitz-Gibbon ST, Grossman AR, Jonikas MC. Li X, et al. Plant Cell. 2016 Feb;28(2):367-87. doi: 10.1105/tpc.15.00465. Epub 2016 Jan 13. Plant Cell. 2016. PMID: 26764374 Free PMC article. - The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility.
Yamamoto R, Song K, Yanagisawa HA, Fox L, Yagi T, Wirschell M, Hirono M, Kamiya R, Nicastro D, Sale WS. Yamamoto R, et al. J Cell Biol. 2013 Apr 15;201(2):263-78. doi: 10.1083/jcb.201211048. Epub 2013 Apr 8. J Cell Biol. 2013. PMID: 23569216 Free PMC article.
References
- Biochemistry. 1971 Jun 22;10(13):2606-17 - PubMed
- Annu Rev Biochem. 1975;44:775-97 - PubMed
- Virology. 1973 Oct;55(2):391-6 - PubMed
- J Cell Biol. 1977 Sep;74(3):747-59 - PubMed
- Annu Rev Microbiol. 1960;14:197-216 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous