Glycine stimulated growth hormone release in man - PubMed (original) (raw)
Glycine stimulated growth hormone release in man
K Kasai et al. Acta Endocrinol (Copenh). 1980 Mar.
Abstract
The influence of glycine, the simplest amino acid, on pituitary function has been investigated in the present study. Different doses (4, 8, or 12 g) of glycine were intravenously infused over 15 or 30 min in normal subjects. Serum levels of GH (growth hormone) and Prl (prolactin) were measured before and after the infusion, and also blood sugar levels were determined. The dose of 4 or 8 g glycine induced a significant increase in serum GH (P less than 0.05 or P less than 0.001, respectively); however, a more pronounced and significant increase in serum GH levels was observed after infusion at a dose of 12 g glycine (P less than 0.001). It was clearly observed that the dose-dependent GH release to intravenous glycine occurred in normal subjects. On the contrary, serum Prl level was not changed significantly, and blood sugar level was transiently, but significantly (P less than 0.05), increased after the infusion of 12 g glycine. The present data suggest that glycine might play an important role in the control of hypothalamic-pituitary function.
Similar articles
- Stimulatory effect of glycine on human growth hormone secretion.
Kasai K, Kobayashi M, Shimoda SI. Kasai K, et al. Metabolism. 1978 Feb;27(2):201-8. doi: 10.1016/0026-0495(78)90165-8. Metabolism. 1978. PMID: 622050 - Effects of cholecystokinin octapeptide on the hypothalamic-pituitary-adrenal axis function and on vasopressin, prolactin and growth hormone release in humans.
Calogero AE, Nicolosi AM, Moncada ML, Coniglione F, Vicari E, Polosa P, D'Agata R. Calogero AE, et al. Neuroendocrinology. 1993 Jul;58(1):71-6. doi: 10.1159/000126514. Neuroendocrinology. 1993. PMID: 8264858 - The influence of amino acids and somatostatin on prolactin and growth hormone release in man.
Bratusch-Marrain P, Waldhäusl W. Bratusch-Marrain P, et al. Acta Endocrinol (Copenh). 1979 Mar;90(3):403-8. doi: 10.1530/acta.0.0900403. Acta Endocrinol (Copenh). 1979. PMID: 425782 - Role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in the control of prolactin, growth hormone and gonadotropin secretion in prepubertal rats.
González LC, Pinilla L, Tena-Sempere M, Aguilar E. González LC, et al. J Endocrinol. 1999 Sep;162(3):417-24. doi: 10.1677/joe.0.1620417. J Endocrinol. 1999. PMID: 10467233 - [The effect of oral administration of glycine on metabolism].
Petzke KJ, Pisarchuk KL, Grigorov YuG, Albrecht V. Petzke KJ, et al. Nahrung. 1987;31(3):207-15. doi: 10.1002/food.19870310304. Nahrung. 1987. PMID: 3302716 Review. German.
Cited by
- Effects of Glycine Supplementation in Drinking Water on the Growth Performance, Intestinal Development, and Genes Expression in the Jejunum of Chicks.
Zheng X, Xie Y, Chen Z, He J, Chen J. Zheng X, et al. Animals (Basel). 2023 Oct 5;13(19):3109. doi: 10.3390/ani13193109. Animals (Basel). 2023. PMID: 37835714 Free PMC article. - The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.
Soh J, Raventhiran S, Lee JH, Lim ZX, Goh J, Kennedy BK, Maier AB. Soh J, et al. Geroscience. 2024 Feb;46(1):219-239. doi: 10.1007/s11357-023-00970-8. Epub 2023 Oct 18. Geroscience. 2024. PMID: 37851316 Free PMC article. - Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age.
Duran-Ortiz S, List EO, Basu R, Kopchick JJ. Duran-Ortiz S, et al. Pituitary. 2021 Jun;24(3):438-456. doi: 10.1007/s11102-020-01117-0. Epub 2021 Jan 18. Pituitary. 2021. PMID: 33459974 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical