Stimulation of eosinophil production in vitro by eosinophilopoietin and spleen-cell-derived eosinophil growth-stimulating factor - PubMed (original) (raw)
- PMID: 7417711
Free article
Stimulation of eosinophil production in vitro by eosinophilopoietin and spleen-cell-derived eosinophil growth-stimulating factor
S H Bartelmez et al. Blood. 1980 Oct.
Free article
Abstract
Eosinophilopoietin (EPP) was previously characterized by the ability to stimulate eosinophil production in vivo, but these studies could not ascertain whether EPP had a direct effect on the bone marrow or acted indirectly by causing release of eosinophilopoietic activity by other tissues. The present studies demonstrate that EPP stimulates eosinophil growth in liquid culture of mouse bone marrow in vitro. The timing of stimulation by EPP in vivo and in vitro were parallel, with maximal eosinophil growth after 48 hr. Moreover, EPP appears similar to, and possible identical with, the eosinophil growth-stimulating substance (EO-GSF) released by antigenic stimulation of immune nonadherent spleen cells. Both EPP and EO-GSF are of low molecular weight, both produce stimulation of eosinophil growth with identical kinetics, and both produced similar dose-response curves in the liquid culture system.
Similar articles
- Eosinophilopoietin. A circulating low molecular weight peptide-like substance which stimulates the production of eosinophils in mice.
Mahmoud AA, Stone MK, Kellermeyer RW. Mahmoud AA, et al. J Clin Invest. 1977 Sep;60(3):675-82. doi: 10.1172/JCI108819. J Clin Invest. 1977. PMID: 893671 Free PMC article. - Cytokine regulation of eosinophil function.
Weller PF. Weller PF. Clin Immunol Immunopathol. 1992 Jan;62(1 Pt 2):S55-9. doi: 10.1016/0090-1229(92)90041-l. Clin Immunol Immunopathol. 1992. PMID: 1728988 Review.
Cited by
- Eosinophil differentiating activity in sera of patients with AIDS under recombinant IL-2 substitution.
Kern P, Dietrich M. Kern P, et al. Blut. 1986 Apr;52(4):249-54. doi: 10.1007/BF00321085. Blut. 1986. PMID: 3486018 - Production of a T-cell hybrid producing a lymphokine stimulating eosinophil differentiation.
Warren DJ, Sanderson CJ. Warren DJ, et al. Immunology. 1985 Apr;54(4):615-23. Immunology. 1985. PMID: 2579895 Free PMC article.