Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates - PubMed (original) (raw)

Comparative Study

. 1980 Mar 11;8(5):1081-96.

doi: 10.1093/nar/8.5.1081.

Free PMC article

Comparative Study

Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates

M J Gait et al. Nucleic Acids Res. 1980.

Free PMC article

Abstract

A phosphotriester solid phase method on a polyamide support has been used to prepare oligodeoxyribonucleotides up to 12 units long. Compared to solid phase phosphodiester synthesis the new methodology is quicker, more flexible and gives 10-60-fold better overall yields.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Anal Biochem. 1970 Apr;34(2):595-8 - PubMed
    1. J Am Chem Soc. 1971 Jun 30;93(13):3272-6 - PubMed
    1. Nucleic Acids Res. 1975 Jun;2(6):773-86 - PubMed
    1. J Am Chem Soc. 1975 Oct 29;97(22):6584-5 - PubMed
    1. J Am Chem Soc. 1975 Dec 10;97(25):7332-7 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources