Idiopathic steatohepatitis in childhood: a multicenter retrospective study - PubMed (original) (raw)
Comparative Study
Idiopathic steatohepatitis in childhood: a multicenter retrospective study
A D Baldridge et al. J Pediatr. 1995 Nov.
Abstract
Objective: To describe the clinical, laboratory, and histopathologic features of idiopathic steatohepatitis in children.
Study design: Retrospective review of all liver biopsies performed at Boston Children's Hospital, Massachusetts General Hospital, and the University of Massachusetts Medical Center from 1991 to 1994. Chart review was performed when biopsies demonstrated steatosis.
Results: Eighty-two patients had biopsy-proven hepatic steatosis. Fourteen patients had fatty liver without evidence of inherited, infectious, autoimmune, endocrinologic, toxicologic, or iatrogenic causes. All 14 patients were obese, averaging 159% of ideal body weight (range, 121% to 222%). Nine patients initially had transient abdominal pain, two had hepatomegaly, and one was identified by incidental laboratory evaluation. These 12 patients had biopsies because of persistent elevations of aminotransferase levels. Two other patients without risk factors for steatosis were identified at staging laparotomy for Hodgkin lymphoma. The 10 boys and 4 girls had an average age of 13.5 years (range, 10 to 18 years). Aminotransferase elevations were modest, with aspartate aminotransferase and alanine aminotransferase values averaging 77 +/- 38 IU and 129 +/- 73 IU, respectively. All had imaging studies demonstrating diffuse fatty change. Histologic examination of biopsy specimens revealed varying degrees of steatosis with inflammation and fibrosis.
Conclusion: Idiopathic steatohepatitis occurs predominantly or exclusively in obese peripubertal children. This entity represents a frequent reason for liver biopsy in this age group. The degree of steatosis, fibrosis, and inflammation does not correlate with symptoms or signs, and significant liver injury with bridging fibrosis may be present.
Similar articles
- Diagnostic value of serum prolidase enzyme activity to predict the liver histological lesions in non-alcoholic fatty liver disease: a surrogate marker to distinguish steatohepatitis from simple steatosis.
Kayadibi H, Gültepe M, Yasar B, Ince AT, Ozcan O, Ipcioglu OM, Kurdas OO, Bolat B, Benek YZ, Guveli H, Atalay S, Ozkara S, Keskin O. Kayadibi H, et al. Dig Dis Sci. 2009 Aug;54(8):1764-71. doi: 10.1007/s10620-008-0535-0. Epub 2008 Nov 7. Dig Dis Sci. 2009. PMID: 18989777 - Apoptosis markers in liver biopsy of nonalcoholic steatohepatitis in pediatric patients.
Valva P, De Matteo E, Galoppo M, Pedreira A, Giacove G, Lezama C, Marco I, Galoppo MC, Preciado MV. Valva P, et al. Hum Pathol. 2008 Dec;39(12):1816-22. doi: 10.1016/j.humpath.2008.04.022. Epub 2008 Aug 20. Hum Pathol. 2008. PMID: 18715620 - Non-alcoholic steatohepatitis in children and adolescents.
Manton ND, Lipsett J, Moore DJ, Davidson GP, Bourne AJ, Couper RT. Manton ND, et al. Med J Aust. 2000 Nov 6;173(9):476-9. doi: 10.5694/j.1326-5377.2000.tb139299.x. Med J Aust. 2000. PMID: 11149304 - Non-alcoholic steatohepatitis in children.
Nanda K. Nanda K. Pediatr Transplant. 2004 Dec;8(6):613-8. doi: 10.1111/j.1399-3046.2004.00241.x. Pediatr Transplant. 2004. PMID: 15598336 Review. - Nonalcoholic steatohepatitis: an evolving diagnosis.
Neuschwander-Tetri BA. Neuschwander-Tetri BA. Can J Gastroenterol. 2000 Apr;14(4):321-6. doi: 10.1155/2000/912735. Can J Gastroenterol. 2000. PMID: 10799085 Review.
Cited by
- Converging Pathways between Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Diabetes in Children.
Faienza MF, Farella I, Khalil M, Portincasa P. Faienza MF, et al. Int J Mol Sci. 2024 Sep 14;25(18):9924. doi: 10.3390/ijms25189924. Int J Mol Sci. 2024. PMID: 39337412 Free PMC article. Review. - Triglyceride Glucose-Waist Circumference Is Superior to the Homeostasis Model Assessment of Insulin Resistance in Identifying Nonalcoholic Fatty Liver Disease in Healthy Subjects.
Kim HS, Cho YK, Kim EH, Lee MJ, Jung CH, Park JY, Kim HK, Lee WJ. Kim HS, et al. J Clin Med. 2021 Dec 23;11(1):41. doi: 10.3390/jcm11010041. J Clin Med. 2021. PMID: 35011784 Free PMC article. - Childhood obesity, cardiovascular and liver health: a growing epidemic with age.
Faienza MF, Chiarito M, Molina-Molina E, Shanmugam H, Lammert F, Krawczyk M, D'Amato G, Portincasa P. Faienza MF, et al. World J Pediatr. 2020 Oct;16(5):438-445. doi: 10.1007/s12519-020-00341-9. Epub 2020 Feb 4. World J Pediatr. 2020. PMID: 32020441 Free PMC article. - Real-world comorbidities and treatment patterns among patients with non-alcoholic fatty liver disease receiving phosphatidylcholine as adjunctive therapy in Russia.
Maev IV, Samsonov AA, Palgova LK, Pavlov CS, Shirokova E, Starostin KM. Maev IV, et al. BMJ Open Gastroenterol. 2019 Aug 18;6(1):e000307. doi: 10.1136/bmjgast-2019-000307. eCollection 2019. BMJ Open Gastroenterol. 2019. PMID: 31523440 Free PMC article. - Cholelithiasis and choledocholithiasis in children; risk factors for development.
Frybova B, Drabek J, Lochmannova J, Douda L, Hlava S, Zemkova D, Mixa V, Kyncl M, Zeman L, Rygl M, Keil R. Frybova B, et al. PLoS One. 2018 May 15;13(5):e0196475. doi: 10.1371/journal.pone.0196475. eCollection 2018. PLoS One. 2018. PMID: 29763444 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical