Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans - PubMed (original) (raw)
. 1995 Nov 9;378(6553):196-9.
doi: 10.1038/378196a0.
Affiliations
- PMID: 7477324
- DOI: 10.1038/378196a0
Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans
E M Jorgensen et al. Nature. 1995.
Abstract
Synaptotagmin, an integral membrane protein of the synaptic vesicle, binds calcium and interacts with proteins of the plasma membrane. These observations suggest several possible functions for synaptotagmin in synaptic vesicle dynamics: it could facilitate exocytosis by promoting calcium-dependent fusion, inhibit exocytosis by preventing fusion, or facilitate endocytosis of synaptic vesicles from the plasma membrane by acting as a receptor for the endocytotic proteins of the clathrin AP2 complex. Here we show that synaptic vesicles are depleted at synaptic terminals in synaptotagmin mutants of the nematode Caenorhabditis elegans. This depletion is not caused by a defect in transport or by increased synaptic vesicle release, but rather by a defect in retrieval or synaptic vesicles from the plasma membrane. Thus we propose that, as well as being involved in exocytosis, synaptotagmin functions in vesicular recycling.
Similar articles
- AP180 maintains the distribution of synaptic and vesicle proteins in the nerve terminal and indirectly regulates the efficacy of Ca2+-triggered exocytosis.
Bao H, Daniels RW, MacLeod GT, Charlton MP, Atwood HL, Zhang B. Bao H, et al. J Neurophysiol. 2005 Sep;94(3):1888-903. doi: 10.1152/jn.00080.2005. Epub 2005 May 11. J Neurophysiol. 2005. PMID: 15888532 - Synaptic vesicle fusion and synaptotagmin: 2B or not 2B?
O'Connor V, Lee AG. O'Connor V, et al. Nat Neurosci. 2002 Sep;5(9):823-4. doi: 10.1038/nn0902-823. Nat Neurosci. 2002. PMID: 12196805 Review. No abstract available. - Binding of synaptotagmin to the alpha-latrotoxin receptor implicates both in synaptic vesicle exocytosis.
Petrenko AG, Perin MS, Davletov BA, Ushkaryov YA, Geppert M, Südhof TC. Petrenko AG, et al. Nature. 1991 Sep 5;353(6339):65-8. doi: 10.1038/353065a0. Nature. 1991. PMID: 1881448 - Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo.
Poskanzer KE, Marek KW, Sweeney ST, Davis GW. Poskanzer KE, et al. Nature. 2003 Dec 4;426(6966):559-63. doi: 10.1038/nature02184. Epub 2003 Nov 23. Nature. 2003. PMID: 14634669 - The synaptic vesicle cycle: a cascade of protein-protein interactions.
Südhof TC. Südhof TC. Nature. 1995 Jun 22;375(6533):645-53. doi: 10.1038/375645a0. Nature. 1995. PMID: 7791897 Review.
Cited by
- The schizophrenia risk gene product miR-137 alters presynaptic plasticity.
Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH. Siegert S, et al. Nat Neurosci. 2015 Jul;18(7):1008-16. doi: 10.1038/nn.4023. Epub 2015 May 25. Nat Neurosci. 2015. PMID: 26005852 Free PMC article. - Drosophila stoned proteins regulate the rate and fidelity of synaptic vesicle internalization.
Stimson DT, Estes PS, Rao S, Krishnan KS, Kelly LE, Ramaswami M. Stimson DT, et al. J Neurosci. 2001 May 1;21(9):3034-44. doi: 10.1523/JNEUROSCI.21-09-03034.2001. J Neurosci. 2001. PMID: 11312288 Free PMC article. - Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I.
Evans GJ, Morgan A. Evans GJ, et al. Biochem J. 2002 Jun 1;364(Pt 2):343-7. doi: 10.1042/BJ20020123. Biochem J. 2002. PMID: 11931641 Free PMC article. - Molecular Signatures Underlying Synaptic Vesicle Cargo Retrieval.
Mori Y, Takamori S. Mori Y, et al. Front Cell Neurosci. 2018 Jan 5;11:422. doi: 10.3389/fncel.2017.00422. eCollection 2017. Front Cell Neurosci. 2018. PMID: 29379416 Free PMC article. Review. - Methods for analyzing neuronal structure and activity in Caenorhabditis elegans.
Emmons SW, Yemini E, Zimmer M. Emmons SW, et al. Genetics. 2021 Aug 9;218(4):iyab072. doi: 10.1093/genetics/iyab072. Genetics. 2021. PMID: 34151952 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials