Transition in specification of embryonic metazoan DNA replication origins - PubMed (original) (raw)
Transition in specification of embryonic metazoan DNA replication origins
O Hyrien et al. Science. 1995.
Abstract
In early Xenopus embryos, in which ribosomal RNA genes (rDNA) are not transcribed, rDNA replication initiates and terminates at 9- to 12-kilobase pair intervals, with no detectable dependence on specific DNA sequences. Resumption of ribosomal RNA (rRNA) synthesis at late blastula and early gastrula is accompanied by a specific repression of replication initiation within transcription units; the frequency of initiation within intergenic spacers remains as high as in early blastula. These results demonstrate that for rRNA genes, circumscribed zones of replication initiation emerge in intergenic DNA during the time in metazoan development when the chromatin is remodeled to allow gene transcription.
Similar articles
- Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos.
Hyrien O, Méchali M. Hyrien O, et al. EMBO J. 1993 Dec;12(12):4511-20. doi: 10.1002/j.1460-2075.1993.tb06140.x. EMBO J. 1993. PMID: 8223461 Free PMC article. - Remodeling of chromatin loops does not account for specification of replication origins during Xenopus development.
Maric C, Hyrien O. Maric C, et al. Chromosoma. 1998 Jun;107(3):155-65. doi: 10.1007/s004120050292. Chromosoma. 1998. PMID: 9639653 - Developmental regulation of replication fork pausing in Xenopus laevis ribosomal RNA genes.
Maric C, Levacher B, Hyrien O. Maric C, et al. J Mol Biol. 1999 Aug 27;291(4):775-88. doi: 10.1006/jmbi.1999.3017. J Mol Biol. 1999. PMID: 10452888 - The ribosomal RNA genes of Tetrahymena: structure and function.
Engberg J. Engberg J. Eur J Cell Biol. 1985 Jan;36(1):133-51. Eur J Cell Biol. 1985. PMID: 3884336 Review. - On spacers.
Fedoroff NV. Fedoroff NV. Cell. 1979 Apr;16(4):697-710. doi: 10.1016/0092-8674(79)90086-2. Cell. 1979. PMID: 378397 Review. No abstract available.
Cited by
- Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals.
Natale DA, Li CJ, Sun WH, DePamphilis ML. Natale DA, et al. EMBO J. 2000 Jun 1;19(11):2728-38. doi: 10.1093/emboj/19.11.2728. EMBO J. 2000. PMID: 10835370 Free PMC article. - Epigenetic landscape for initiation of DNA replication.
Sherstyuk VV, Shevchenko AI, Zakian SM. Sherstyuk VV, et al. Chromosoma. 2014 Jun;123(3):183-99. doi: 10.1007/s00412-013-0448-3. Epub 2013 Dec 17. Chromosoma. 2014. PMID: 24337246 Review. - Genome-wide depletion of replication initiation events in highly transcribed regions.
Martin MM, Ryan M, Kim R, Zakas AL, Fu H, Lin CM, Reinhold WC, Davis SR, Bilke S, Liu H, Doroshow JH, Reimers MA, Valenzuela MS, Pommier Y, Meltzer PS, Aladjem MI. Martin MM, et al. Genome Res. 2011 Nov;21(11):1822-32. doi: 10.1101/gr.124644.111. Epub 2011 Aug 3. Genome Res. 2011. PMID: 21813623 Free PMC article. - Organization of DNA Replication Origin Firing in Xenopus Egg Extracts: The Role of Intra-S Checkpoint.
Ciardo D, Haccard O, Narassimprakash H, Arbona JM, Hyrien O, Audit B, Marheineke K, Goldar A. Ciardo D, et al. Genes (Basel). 2021 Aug 9;12(8):1224. doi: 10.3390/genes12081224. Genes (Basel). 2021. PMID: 34440398 Free PMC article. - Replication landscape of the human genome.
Petryk N, Kahli M, d'Aubenton-Carafa Y, Jaszczyszyn Y, Shen Y, Silvain M, Thermes C, Chen CL, Hyrien O. Petryk N, et al. Nat Commun. 2016 Jan 11;7:10208. doi: 10.1038/ncomms10208. Nat Commun. 2016. PMID: 26751768 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources