What to do at an end: DNA double-strand-break repair - PubMed (original) (raw)
Review
What to do at an end: DNA double-strand-break repair
D T Weaver. Trends Genet. 1995 Oct.
Abstract
Repairing chromosome breaks is essential to cell survival. A major lethal effect of ionizing radiation (IR) damage is the creation of double-strand DNA breaks. Recently, a number of mammalian cell mutants that are sensitive to IR damage have been described, revealing a unique repair pathway. The DNA-dependent protein kinase (DNA-PK) is necessary for double-strand-break repair and lymphoid V(D)J recombination. DNA-PK consists of three subunits: the Ku autoantigen heterodimer and a kinase (DNA-PKCS) that is deficient in mouse scid mutant cells.
Similar articles
- DNA-dependent protein kinase does not play a role in adaptive survival responses to ionizing radiation.
Odegaard E, Yang CR, Boothman DA. Odegaard E, et al. Environ Health Perspect. 1998 Feb;106 Suppl 1(Suppl 1):301-5. doi: 10.1289/ehp.98106s1301. Environ Health Perspect. 1998. PMID: 9539023 Free PMC article. - Ku, a DNA repair protein with multiple cellular functions?
Featherstone C, Jackson SP. Featherstone C, et al. Mutat Res. 1999 May 14;434(1):3-15. doi: 10.1016/s0921-8777(99)00006-3. Mutat Res. 1999. PMID: 10377944 Review. - Mechanisms of DNA double strand break repair and chromosome aberration formation.
Iliakis G, Wang H, Perrault AR, Boecker W, Rosidi B, Windhofer F, Wu W, Guan J, Terzoudi G, Pantelias G. Iliakis G, et al. Cytogenet Genome Res. 2004;104(1-4):14-20. doi: 10.1159/000077461. Cytogenet Genome Res. 2004. PMID: 15162010 Review. - Regulation and repair of double-strand DNA breaks.
Weaver DT. Weaver DT. Crit Rev Eukaryot Gene Expr. 1996;6(4):345-75. doi: 10.1615/critreveukargeneexpr.v6.i4.20. Crit Rev Eukaryot Gene Expr. 1996. PMID: 8959372 Review. - Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions.
Jin S, Weaver DT. Jin S, et al. EMBO J. 1997 Nov 17;16(22):6874-85. doi: 10.1093/emboj/16.22.6874. EMBO J. 1997. PMID: 9362500 Free PMC article.
Cited by
- Oxidative stress-induced chromosome breaks within the ABL gene: a model for chromosome rearrangement in nasopharyngeal carcinoma.
Tan SN, Sim SP, Khoo AS. Tan SN, et al. Hum Genomics. 2018 Jun 18;12(1):29. doi: 10.1186/s40246-018-0160-8. Hum Genomics. 2018. PMID: 29914565 Free PMC article. - Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells.
Zeng Q, Wang Z, Liu C, Gong Z, Yang L, Jiang L, Ma Z, Qian Y, Yang Y, Kang H, Hong S, Bu Y, Hu G. Zeng Q, et al. Mol Cell Biochem. 2016 Jul;418(1-2):137-46. doi: 10.1007/s11010-016-2739-5. Epub 2016 Jun 23. Mol Cell Biochem. 2016. PMID: 27334757 - A coumarin derivative (RKS262) inhibits cell-cycle progression, causes pro-apoptotic signaling and cytotoxicity in ovarian cancer cells.
Singh RK, Lange TS, Kim KK, Brard L. Singh RK, et al. Invest New Drugs. 2011 Feb;29(1):63-72. doi: 10.1007/s10637-009-9335-4. Epub 2009 Oct 29. Invest New Drugs. 2011. PMID: 19865799 Free PMC article. - Crystal structure of MutS2 endonuclease domain and the mechanism of homologous recombination suppression.
Fukui K, Nakagawa N, Kitamura Y, Nishida Y, Masui R, Kuramitsu S. Fukui K, et al. J Biol Chem. 2008 Nov 28;283(48):33417-27. doi: 10.1074/jbc.M806755200. Epub 2008 Oct 6. J Biol Chem. 2008. PMID: 18838375 Free PMC article. - A comprehensive continuous-time model for the appearance of CGH signal due to chromosomal missegregations during mitosis.
Desper R, Difilippantonio MJ, Ried T, Schäffer AA. Desper R, et al. Math Biosci. 2005 Sep;197(1):67-87. doi: 10.1016/j.mbs.2005.05.005. Math Biosci. 2005. PMID: 16043196 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources