Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence - PubMed (original) (raw)

Comparative Study

. 1996 Jan;155(1):105-9; discussion 109-10.

Affiliations

• PMID: 7490803

Comparative Study

Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence

M Kriegmair et al. J Urol. 1996 Jan.

Abstract

Purpose: We determined whether the sensitivity of detecting dysplasia or early bladder cancer can be improved by 5-aminolevulinic acid induced porphyrin fluorescence.

Materials and methods: A 3% 5-aminolevulinic acid solution was instilled intravesically before cystoscopy in 104 patients. The 5-aminolevulinic acid induced porphyrin fluorescence was excited by violet light from a krypton ion laser (wavelength 406.7 nm.).

Results: The sensitivity of the fluorescence cystoscopy (96.9%) was significantly (p < 0.0001) greater than that of white light cystoscopy (72.7%). There was no impact on specificity.

Conclusions: Due to the high sensitivity of the procedure fluorescence guided biopsies are recommended instead of random biopsies.

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• Urothelial malignancy--much promise but little progress.
  Bahnson RR. Bahnson RR. J Urol. 1996 Jan;155(1):122. doi: 10.1016/s0022-5347(01)66565-0. J Urol. 1996. PMID: 7490807 No abstract available.

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