Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac - PubMed (original) (raw)
Clinical Trial
. 1995 Dec 1;86(11):4063-75.
J D White, J A Carrasquillo, J C Reynolds, C H Paik, O A Gansow, M W Brechbiel, E S Jaffe, T A Fleisher, C K Goldman, L E Top, R Bamford, E Zaknoen, E Roessler, C Kasten-Sportes, R England, H Litou, J A Johnson, T Jackson-White, A Manns, B Hanchard, R P Junghans, D L Nelson
Affiliations
- PMID: 7492762
Free article
Clinical Trial
Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac
T A Waldmann et al. Blood. 1995.
Free article
Abstract
Adult T-cell leukemia (ATL) is a malignancy of mature lymphocytes caused by the retrovirus human T-cell lymphotropic virus-I. It is an aggressive leukemia with a median survival time of 9 months; no chemotherapy regimen appears successful in inducing long-term disease-free survival. The scientific basis of the present study is that ATL cells express high-affinity interleukin-2 receptors identified by the anti-Tac monoclonal antibody, whereas normal resting cells do not. To exploit this difference, we administered anti-Tac armed with Yttrium-90 (90Y) to 18 patients with ATL initially (first 9 patients) in a phase I dose-escalation trial and subsequently (second group of 9 patients) in a phase II trial involving a uniform 10-mCi dose of 90Y-labeled anti-Tac. Patients undergoing a remission were permitted to receive up to eight additional doses. At the 5- to 15-mCi doses used, 9 of 16 evaluable patients responded to 90Y anti-Tac with a partial (7 patients) or complete (2 patients) remission. The responses observed represent improved efficacy in terms of length of remission when compared with previous results with unmodified anti-Tac. Clinically meaningful (> or = grade 3) toxicity was largely limited to the hematopoietic system. In conclusion, radioimmunotherapy with 90Y anti-Tac directed toward the IL-2R expressed on ATL cells may provide a useful approach for treatment of this aggressive malignancy.
Comment in
- Radioimmunotherapy: promising treatment of aggressive adult T-cell leukemia?
Taguchi H. Taguchi H. Blood. 1996 Jun 15;87(12):5379-80. Blood. 1996. PMID: 8652853 No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources