Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase - PubMed (original) (raw)
Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase
M Nguyen et al. Genetics. 1995 Jun.
Abstract
We characterized 18 genes from Caenorhabditis elegans that, when mutated, confer recessive resistance to inhibitors of acetylcholinesterase. These include previously described genes as well as newly identified genes; they encode essential as well as nonessential functions. In the absence of acetylcholinesterase inhibitors, the different mutants display a wide range of behavioral deficits, from mild uncoordination to almost complete paralysis. Measurements of acetylcholine levels in these mutants suggest that some of the genes are involved in presynaptic functions.
Similar articles
- A genetic selection for Caenorhabditis elegans synaptic transmission mutants.
Miller KG, Alfonso A, Nguyen M, Crowell JA, Johnson CD, Rand JB. Miller KG, et al. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12593-8. doi: 10.1073/pnas.93.22.12593. Proc Natl Acad Sci U S A. 1996. PMID: 8901627 Free PMC article. - Paradigms for pharmacological characterization of C. elegans synaptic transmission mutants.
Locke C, Berry K, Kautu B, Lee K, Caldwell K, Caldwell G. Locke C, et al. J Vis Exp. 2008 Aug 18;(18):837. doi: 10.3791/837. J Vis Exp. 2008. PMID: 19066504 Free PMC article. - Neuronally expressed Ras-family GTPase Di-Ras modulates synaptic activity in Caenorhabditis elegans.
Tada M, Gengyo-Ando K, Kobayashi T, Fukuyama M, Mitani S, Kontani K, Katada T. Tada M, et al. Genes Cells. 2012 Sep;17(9):778-89. doi: 10.1111/j.1365-2443.2012.01627.x. Epub 2012 Aug 16. Genes Cells. 2012. PMID: 22897658 - Preclinical pharmacology of metrifonate.
Jann MW. Jann MW. Pharmacotherapy. 1998 Mar-Apr;18(2 Pt 2):55-67; discussion 79-82. Pharmacotherapy. 1998. PMID: 9543466 Review. - Acetylcholinesterase genes in the nematode Caenorhabditis elegans.
Combes D, Fedon Y, Toutant JP, Arpagaus M. Combes D, et al. Int Rev Cytol. 2001;209:207-39. doi: 10.1016/s0074-7696(01)09013-1. Int Rev Cytol. 2001. PMID: 11580201 Review.
Cited by
- The role of kinesin-1 in neuronal dense core vesicle transport, locomotion and lifespan regulation in C. elegans.
Gavrilova A, Boström A, Korabel N, Fedotov S, Poulin GB, Allan VJ. Gavrilova A, et al. J Cell Sci. 2024 Sep 1;137(17):jcs262148. doi: 10.1242/jcs.262148. Epub 2024 Sep 6. J Cell Sci. 2024. PMID: 39171448 Free PMC article. - Vitamin B12 produced by gut bacteria modulates cholinergic signalling.
Kang WK, Florman JT, Araya A, Fox BW, Thackeray A, Schroeder FC, Walhout AJM, Alkema MJ. Kang WK, et al. Nat Cell Biol. 2024 Jan;26(1):72-85. doi: 10.1038/s41556-023-01299-2. Epub 2024 Jan 2. Nat Cell Biol. 2024. PMID: 38168768 - The MA Helix Is Important for Receptor Assembly and Function in the α4β2 nACh Receptor.
Fricska DI, Mesoy SM, Lummis SCR. Fricska DI, et al. Membranes (Basel). 2023 Nov 29;13(12):891. doi: 10.3390/membranes13120891. Membranes (Basel). 2023. PMID: 38132895 Free PMC article. - The homeodomain transcriptional regulator DVE-1 directs a program for synapse elimination during circuit remodeling.
Alexander KD, Ramachandran S, Biswas K, Lambert CM, Russell J, Oliver DB, Armstrong W, Rettler M, Liu S, Doitsidou M, Bénard C, Walker AK, Francis MM. Alexander KD, et al. Nat Commun. 2023 Nov 18;14(1):7520. doi: 10.1038/s41467-023-43281-4. Nat Commun. 2023. PMID: 37980357 Free PMC article. - Double mutation of open syntaxin and UNC-18 P334A leads to excitatory-inhibitory imbalance and impairs multiple aspects of C. elegans behavior.
Huang M, Wang Y, Chow CH, Stepien KP, Indrawinata K, Xu J, Argiropoulos P, Xie X, Sugita K, Tien CW, Lee S, Monnier PP, Rizo J, Gao S, Sugita S. Huang M, et al. bioRxiv [Preprint]. 2023 Nov 10:2023.08.18.553709. doi: 10.1101/2023.08.18.553709. bioRxiv. 2023. PMID: 37645974 Free PMC article. Preprint.
References
- Genetics. 1974 May;77(1):71-94 - PubMed
- Nature. 1993 Nov 25;366(6453):347-51 - PubMed
- Genetics. 1981 Feb;97(2):261-79 - PubMed
- Genetics. 1981 Feb;97(2):281-305 - PubMed
- J Neurosci. 1983 Feb;3(2):359-68 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases