Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation - PubMed (original) (raw)
Comparative Study
. 1995 Nov 24;270(47):27995-8.
doi: 10.1074/jbc.270.47.27995.
Affiliations
- PMID: 7499279
- DOI: 10.1074/jbc.270.47.27995
Free article
Comparative Study
Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation
S Bagrodia et al. J Biol Chem. 1995.
Free article
Abstract
The PAK family of protein kinases has been suggested as a potential target of the Cdc42 and Rac GTPases based on studies in vitro. We show that PAK-3 is activated by Cdc42 in vivo. Both, activated (GTPase-defective) Cdc42 and a constitutively active PAK-3 mutant stimulated the activity of Jun kinase 1 (JNK1) in transfected cells. Activated Cdc42 also stimulated the activity of the related p38 mitogen-activated protein kinase but was a less effective activator of ERK2. The effect of Cdc42 on JNK activity was similar to that of the potent inflammatory cytokine interleukin-1 (IL-1). The observation that a dominant-negative Cdc42 mutant inhibited IL-1 activation of JNK1 indicates a role for Cdc42 in IL-1 signaling. These results suggest that Cdc42 and PAK may mediate the effects of cytokines on transcriptional regulation.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous