Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains - PubMed (original) (raw)

. 1994 Feb 10;367(6463):532-8.

doi: 10.1038/367532a0.

Affiliations

• PMID: 7509040
• DOI: 10.1038/367532a0

Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains

B J Graves et al. Nature. 1994.

Abstract

The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation.

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