Molecular and cellular mechanisms of general anaesthesia - PubMed (original) (raw)
Review
. 1994 Feb 17;367(6464):607-14.
doi: 10.1038/367607a0.
Affiliations
- PMID: 7509043
- DOI: 10.1038/367607a0
Review
Molecular and cellular mechanisms of general anaesthesia
N P Franks et al. Nature. 1994.
Abstract
General anaesthetics are much more selective than is usually appreciated and may act by binding to only a small number of targets in the central nervous system. At surgical concentrations their principal effects are on ligand-gated (rather than voltage-gated) ion channels, with potentiation of postsynaptic inhibitory channel activity best fitting the pharmacological profile observed in general anaesthesia. Although the role of second messengers remains uncertain, it is now clear that anaesthetics act directly on proteins rather than on lipids.
Comment in
- HCN1 Channels as Targets for Volatile Anesthetics: Coming to the Fore.
Goldstein PA. Goldstein PA. Anesth Analg. 2015 Sep;121(3):594-596. doi: 10.1213/ANE.0000000000000871. Anesth Analg. 2015. PMID: 26287292 No abstract available.
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