Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor - PubMed (original) (raw)
Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor
H Maeda et al. Jpn J Cancer Res. 1994 Apr.
Abstract
A newly discovered nitric oxide radical scavenger, an imidazolineoxyl N-oxide derivative, was used to investigate the role of nitric oxide radical (.NO) in the vascular permeability enhancement of solid tumor. Sarcoma-180 solid tumor in ddY mice was used for this experiment. Electron spin resonance spectroscopy was used to quantitate the reacted and unreacted scavenger. The results showed that extensive extravasation, assessed by intravenous injection of Evans blue, could be greatly suppressed by both .NO scavenger administered orally and .NO synthase inhibitor administrated intraperitoneally. This indicates that .NO is responsible for the vascular permeability in solid tumors.
Similar articles
- A new nitric oxide scavenger, imidazolineoxyl N-oxide derivative, and its effects in pathophysiology and microbiology.
Maeda H, Akaike T, Yoshida M, Sato K, Noguchi Y. Maeda H, et al. Curr Top Microbiol Immunol. 1995;196:37-50. doi: 10.1007/978-3-642-79130-7_5. Curr Top Microbiol Immunol. 1995. PMID: 7543398 Review. No abstract available. - Role of eicosanoids but not nitric oxide in the platelet-activating factor-induced increase in vascular permeability in mouse skin.
Fujii E, Irie K, Uchida Y, Ohba K, Muraki T. Fujii E, et al. Eur J Pharmacol. 1995 Feb 6;273(3):267-72. doi: 10.1016/0014-2999(94)00697-6. Eur J Pharmacol. 1995. PMID: 7537684 - Possible role of nitric oxide in 5-hydroxytryptamine-induced increase in vascular permeability in mouse skin.
Fujii E, Irie K, Uchida Y, Tsukahara F, Muraki T. Fujii E, et al. Naunyn Schmiedebergs Arch Pharmacol. 1994 Oct;350(4):361-4. doi: 10.1007/BF00178952. Naunyn Schmiedebergs Arch Pharmacol. 1994. PMID: 7531292 - The link between infection and cancer: tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect.
Maeda H. Maeda H. Cancer Sci. 2013 Jul;104(7):779-89. doi: 10.1111/cas.12152. Epub 2013 Apr 22. Cancer Sci. 2013. PMID: 23495730 Free PMC article. Review.
Cited by
- Targeting collagen in tumor extracellular matrix as a novel targeted strategy in cancer immunotherapy.
Liu J, Pan D, Huang X, Wang S, Chen H, Zhu YZ, Ye L. Liu J, et al. Front Oncol. 2023 Aug 24;13:1225483. doi: 10.3389/fonc.2023.1225483. eCollection 2023. Front Oncol. 2023. PMID: 37692860 Free PMC article. Review. - Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications.
Andrabi SM, Sharma NS, Karan A, Shahriar SMS, Cordon B, Ma B, Xie J. Andrabi SM, et al. Adv Sci (Weinh). 2023 Oct;10(30):e2303259. doi: 10.1002/advs.202303259. Epub 2023 Aug 26. Adv Sci (Weinh). 2023. PMID: 37632708 Free PMC article. Review. - Enhanced Permeability and Retention Effect as a Ubiquitous and Epoch-Making Phenomenon for the Selective Drug Targeting of Solid Tumors.
Islam W, Niidome T, Sawa T. Islam W, et al. J Pers Med. 2022 Nov 28;12(12):1964. doi: 10.3390/jpm12121964. J Pers Med. 2022. PMID: 36556185 Free PMC article. Review. - Increased PDT Efficacy When Associated with Nitroglycerin: A Study on Retinoblastoma Xenografted on Mice.
Thomas CD, Lupu M, Poyer F, Maillard P, Mispelter J. Thomas CD, et al. Pharmaceuticals (Basel). 2022 Aug 10;15(8):985. doi: 10.3390/ph15080985. Pharmaceuticals (Basel). 2022. PMID: 36015132 Free PMC article. - Development of a Selective Tumor-Targeted Drug Delivery System: Hydroxypropyl-Acrylamide Polymer-Conjugated Pirarubicin (P-THP) for Pediatric Solid Tumors.
Makimoto A, Fang J, Maeda H. Makimoto A, et al. Cancers (Basel). 2021 Jul 23;13(15):3698. doi: 10.3390/cancers13153698. Cancers (Basel). 2021. PMID: 34359599 Free PMC article. Review.
References
- ) Akaike , T. , Yoshida , M. , Miyamoto , Y. , Sato , K. , Kohno , M. , Sasamoto , K. , Miyazaki , K. , Ueda , S. and Maeda , H.Antagonistic action of imidazolineoxyl N‐oxides against endothelium‐derived relaxing factor/⋅NO through a radical reaction . Biochemistry , 32 , 827 – 832 ( 1993. ). - PubMed
- ) Akaike , T. , Yoshida , M. , Sato , K. , Ueda , S. and Meada , H.Therapeutic effect of a new ⋅NO‐antidote, imidazolineoxyl N‐oxide on endotoxin shock in rats . Proc. 3rd Int. Meet. on Biol. Nitric Oxide ( 1994. ), in press . - PubMed
- ) Maeda , H. , Akaike , T. , Yoshida , M. , Sato , K. and Noguchi , Y.A new class of antidote of nitric oxide, imidazolineoxyl N‐oxide derivative: therapeutic effect of endotoxin shock and suppressive effect on vascular permeability in solid tumor . In “ The Role of Nitric Oxide in Physiology and Pathology ,” ed. Koprowski H. , Springer‐Verlag; , Berlin ( 1994. ), in press .
- ) Folkman , J.What is the evidence that tumors are angiogenesis dependent ? J. Natl. Cancer Inst. , 82 , 4 – 6 ( 1990. ). - PubMed
- ) Skinner , S. A. , Tutton , P. J. M. and O'Brein , P. E.Microvascular architecture of experimental colon tumors in the rats . Cancer Res. , 50 , 2411 – 2417 ( 1990. ). - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources