Statistics of RNA melting kinetics - PubMed (original) (raw)

Statistics of RNA melting kinetics

M Tacker et al. Eur Biophys J. 1994.

Abstract

We present and study the behavior of a simple kinetic model for the melting of RNA secondary structures, given that those structures are known. The model is then used as a map that assigns structure dependent overall rate constants of melting (or refolding) to a sequence. This induces a "landscape" of reaction rates, or activation energies, over the space of sequences with fixed length. We study the distribution and the correlation structure of these activation energies.

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