Frequent expression of 75 kDa nerve growth factor receptor and phosphotyrosine in human peripheral nerve tumours: an immunohistochemical study on paraffin-embedded tissues - PubMed (original) (raw)
Frequent expression of 75 kDa nerve growth factor receptor and phosphotyrosine in human peripheral nerve tumours: an immunohistochemical study on paraffin-embedded tissues
N Hoshi et al. Virchows Arch. 1994.
Abstract
One hundred and three benign, and 10 malignant peripheral nerve tumours were examined immunohistochemically for expression of 75 kDa nerve growth factor receptor (NGFR). In benign tumours NGFR was demonstrated at 61% in neurinoma, 71% in neurofibroma, 93% in neurofibromatosis and 90% in traumatic neuroma. Malignant neurogenic tumours were 100% positive for NGFR. Phosphotyrosine-immunoreactivity was detected in 76% of NGFR-positive tumours but the frequency of immunostained tumour cells was low. These results suggest that both benign and malignant peripheral nerve tumours express 75 kDa NGFR. The receptor seems to serve as growth signal transduction of the tumour cells in terms of phosphorylation of the tyrosine residue of the receptor or the target protein of the NGFR protein tyrosine kinase.
Similar articles
- [Expression of nerve growth factor receptor in human benign peripheral nerve sheath tumor].
Yasuda T, Sobue G, Hashizume Y, Mitsuma T, Takahashi A. Yasuda T, et al. Rinsho Shinkeigaku. 1989 Apr;29(4):411-20. Rinsho Shinkeigaku. 1989. PMID: 2558831 Japanese. - Epithelial membrane antigen expression by the perineurium of peripheral nerve and in peripheral nerve tumours.
Theaker JM, Gatter KC, Puddle J. Theaker JM, et al. Histopathology. 1988 Aug;13(2):171-9. doi: 10.1111/j.1365-2559.1988.tb02022.x. Histopathology. 1988. PMID: 3169685 - Expression of immunoreactivities to 75 kDa nerve growth factor receptor, trk gene product and phosphotyrosine in granular cell tumors.
Hoshi N, Tsu-ura Y, Watanabe K, Suzuki T, Kasukawa R, Suzuki T. Hoshi N, et al. Pathol Int. 1995 Oct;45(10):748-56. doi: 10.1111/j.1440-1827.1995.tb03392.x. Pathol Int. 1995. PMID: 8563936 - Neurofibroma and schwannoma.
Ferner RE, O'Doherty MJ. Ferner RE, et al. Curr Opin Neurol. 2002 Dec;15(6):679-84. doi: 10.1097/01.wco.0000044763.39452.aa. Curr Opin Neurol. 2002. PMID: 12447105 Review. - [Pathologic characteristics of the most frequent peripheral nerve tumors].
Coulon A, Milin S, Laban E, Debiais C, Jamet C, Goujon JM. Coulon A, et al. Neurochirurgie. 2009 Oct;55(4-5):454-8. doi: 10.1016/j.neuchi.2009.07.001. Epub 2009 Sep 9. Neurochirurgie. 2009. PMID: 19744677 Review. French.
Cited by
- Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein.
Giovannini M, Robanus-Maandag E, Niwa-Kawakita M, van der Valk M, Woodruff JM, Goutebroze L, Mérel P, Berns A, Thomas G. Giovannini M, et al. Genes Dev. 1999 Apr 15;13(8):978-86. doi: 10.1101/gad.13.8.978. Genes Dev. 1999. PMID: 10215625 Free PMC article. - Tissue Localization of Nerve Growth Factor Receptors: trk A and Low-Affinity Nerve Growth Factor Receptor in Neuroblastoma, Pheochromocytoma, and Retinoblastoma.
Kimura N, Nakamura M, Kimura I, Nagura H. Kimura N, et al. Endocr Pathol. 1996 Winter;7(4):281-289. doi: 10.1007/BF02739835. Endocr Pathol. 1996. PMID: 12114799 - Characterization of a newly established schwannoma cell line from a sporadic vestibular schwannoma patient.
Xue L, He W, Wang Z, Chen H, Wang Z, Wu H. Xue L, et al. Am J Transl Res. 2021 Aug 15;13(8):8787-8803. eCollection 2021. Am J Transl Res. 2021. PMID: 34539995 Free PMC article. - Synergistic Effect of Erastin Combined with Nutlin-3 on Vestibular Schwannoma Cells as p53 Modulates Erastin-Induced Ferroptosis Response.
He W, Shu W, Xue L, Wang Y, Chai Y, Wu H, Wang Z. He W, et al. J Oncol. 2022 Mar 21;2022:7507857. doi: 10.1155/2022/7507857. eCollection 2022. J Oncol. 2022. PMID: 35359340 Free PMC article.
References
- J Neurochem. 1992 Oct;59(4):1381-91 - PubMed
- J Histochem Cytochem. 1988 Apr;36(4):383-9 - PubMed
- Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7242-6 - PubMed
- Proc Natl Acad Sci U S A. 1984 Nov;81(21):6681-5 - PubMed
- Am J Pathol. 1988 Jul;132(1):152-60 - PubMed
MeSH terms
Substances
LinkOut - more resources
Research Materials