Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity - PubMed (original) (raw)
. 1994 Jul 22;265(5171):528-30.
doi: 10.1126/science.7518614.
Affiliations
- PMID: 7518614
- DOI: 10.1126/science.7518614
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity
D Kägi et al. Science. 1994.
Abstract
Two molecular mechanisms of T cell-mediated cytotoxicity, one perforin-based, the other Fas-based, have been demonstrated. To determine the extent of their contribution to T cell-mediated cytotoxicity, a range of effector cells from normal control or perforin-deficient mice were tested against a panel of target cells with various levels of Fas expression. All cytotoxicity observed was due to either of these mechanisms, and no third mechanism was detected. Thus, the perforin- and Fas-based mechanisms may account for all T cell-mediated cytotoxicity in short-term in vitro assays.
Similar articles
- MRL/lpr CD4- CD8- and CD8+ T cells, respectively, mediate Fas-dependent and perforin cytotoxic pathways.
Benihoud K, Bonardelle D, Bobé P, Kiger N. Benihoud K, et al. Eur J Immunol. 1997 Feb;27(2):415-20. doi: 10.1002/eji.1830270211. Eur J Immunol. 1997. PMID: 9045912 - Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways.
Lowin B, Hahne M, Mattmann C, Tschopp J. Lowin B, et al. Nature. 1994 Aug 25;370(6491):650-2. doi: 10.1038/370650a0. Nature. 1994. PMID: 7520535 - Fas-based T cell-mediated cytotoxicity.
Golstein P. Golstein P. Curr Top Microbiol Immunol. 1995;198:25-37. doi: 10.1007/978-3-642-79414-8_2. Curr Top Microbiol Immunol. 1995. PMID: 7539731 Review. No abstract available. - Fas- and perforin-independent mechanism of cytotoxic T lymphocyte.
Kajino K, Kajino Y, Greene MI. Kajino K, et al. Immunol Res. 1998;17(1-2):89-93. doi: 10.1007/BF02786434. Immunol Res. 1998. PMID: 9479571 Review.
Cited by
- Dendritic cell-directed vaccination with a lentivector encoding PSCA for prostate cancer in mice.
Xiao L, Joo KI, Lim M, Wang P. Xiao L, et al. PLoS One. 2012;7(11):e48866. doi: 10.1371/journal.pone.0048866. Epub 2012 Nov 6. PLoS One. 2012. PMID: 23139820 Free PMC article. - Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection.
Sakhdari A, Mujib S, Vali B, Yue FY, MacParland S, Clayton K, Jones RB, Liu J, Lee EY, Benko E, Kovacs C, Gommerman J, Kaul R, Ostrowski MA. Sakhdari A, et al. PLoS One. 2012;7(7):e40146. doi: 10.1371/journal.pone.0040146. Epub 2012 Jul 5. PLoS One. 2012. PMID: 22792231 Free PMC article. - A strategy to protect off-the-shelf cell therapy products using virus-specific T-cells engineered to eliminate alloreactive T-cells.
Quach DH, Becerra-Dominguez L, Rouce RH, Rooney CM. Quach DH, et al. J Transl Med. 2019 Jul 24;17(1):240. doi: 10.1186/s12967-019-1988-y. J Transl Med. 2019. PMID: 31340822 Free PMC article. - T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions.
Benagiano M, Azzurri A, Ciervo A, Amedei A, Tamburini C, Ferrari M, Telford JL, Baldari CT, Romagnani S, Cassone A, D'Elios MM, Del Prete G. Benagiano M, et al. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6658-63. doi: 10.1073/pnas.1135726100. Epub 2003 May 9. Proc Natl Acad Sci U S A. 2003. PMID: 12740434 Free PMC article. - Loss of Fas-ligand expression in mouse keratinocytes during UV carcinogenesis.
Ouhtit A, Gorny A, Muller HK, Hill LL, Owen-Schaub L, Ananthaswamy HN. Ouhtit A, et al. Am J Pathol. 2000 Dec;157(6):1975-81. doi: 10.1016/S0002-9440(10)64836-5. Am J Pathol. 2000. PMID: 11106570 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous