No requirement of reactive oxygen intermediates in Fas-mediated apoptosis - PubMed (original) (raw)
No requirement of reactive oxygen intermediates in Fas-mediated apoptosis
H Hug et al. FEBS Lett. 1994.
Free article
Abstract
Fas is a cell surface molecule that mediates apoptosis, but the intracellular mechanisms leading to apoptosis are not well understood. It is known that diethylmaleate (DEM)-induced cell death can be blocked by substances with antioxidant activity. Here we have studied whether antioxidants have any effect on Fas-mediated apoptosis and show that they are not able to block Fas-mediated apoptosis. Therefore, it seems that reactive oxygen intermediate (ROI)-dependent and -independent mechanisms which lead to apoptosis do exist. Fas-mediated apoptosis probably proceeds via a ROI-independent pathway.
Similar articles
- Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes.
Nagai H, Matsumaru K, Feng G, Kaplowitz N. Nagai H, et al. Hepatology. 2002 Jul;36(1):55-64. doi: 10.1053/jhep.2002.33995. Hepatology. 2002. PMID: 12085349 - Fas-induced programmed cell death is mediated by a Ras-regulated O2- synthesis.
Gulbins E, Brenner B, Schlottmann K, Welsch J, Heinle H, Koppenhoefer U, Linderkamp O, Coggeshall KM, Lang F. Gulbins E, et al. Immunology. 1996 Oct;89(2):205-12. doi: 10.1046/j.1365-2567.1996.d01-743.x. Immunology. 1996. PMID: 8943716 Free PMC article. - Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway.
Um HD, Orenstein JM, Wahl SM. Um HD, et al. J Immunol. 1996 May 1;156(9):3469-77. J Immunol. 1996. PMID: 8617975 - The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation.
Kolesnick RN, Haimovitz-Friedman A, Fuks Z. Kolesnick RN, et al. Biochem Cell Biol. 1994 Nov-Dec;72(11-12):471-4. doi: 10.1139/o94-063. Biochem Cell Biol. 1994. PMID: 7544586 Review. - The role of the Fas/FasL signaling pathway in environmental toxicant-induced testicular cell apoptosis: An update.
Wang M, Su P. Wang M, et al. Syst Biol Reprod Med. 2018 Apr;64(2):93-102. doi: 10.1080/19396368.2017.1422046. Epub 2018 Jan 4. Syst Biol Reprod Med. 2018. PMID: 29299971 Review.
Cited by
- GSH protects against oxidative stress and toxicity in VL-17A cells exposed to high glucose.
Kumar SM, Swaminathan K, Clemens DL, Dey A. Kumar SM, et al. Eur J Nutr. 2015 Mar;54(2):223-34. doi: 10.1007/s00394-014-0703-2. Epub 2014 Apr 23. Eur J Nutr. 2015. PMID: 24756473 - The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation.
Wang L, Azad N, Kongkaneramit L, Chen F, Lu Y, Jiang BH, Rojanasakul Y. Wang L, et al. J Immunol. 2008 Mar 1;180(5):3072-80. doi: 10.4049/jimmunol.180.5.3072. J Immunol. 2008. PMID: 18292530 Free PMC article. - Bcl-2 family proteins as regulators of oxidative stress.
Susnow N, Zeng L, Margineantu D, Hockenbery DM. Susnow N, et al. Semin Cancer Biol. 2009 Feb;19(1):42-9. doi: 10.1016/j.semcancer.2008.12.002. Epub 2008 Dec 24. Semin Cancer Biol. 2009. PMID: 19138742 Free PMC article. Review. - Cytotoxic effect of p-Coumaric acid on neuroblastoma, N2a cell via generation of reactive oxygen species leading to dysfunction of mitochondria inducing apoptosis and autophagy.
Shailasree S, Venkataramana M, Niranjana SR, Prakash HS. Shailasree S, et al. Mol Neurobiol. 2015 Feb;51(1):119-30. doi: 10.1007/s12035-014-8700-2. Epub 2014 Apr 24. Mol Neurobiol. 2015. PMID: 24760364 - Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell apoptosis.
Creagh EM, Cotter TG. Creagh EM, et al. Immunology. 1999 May;97(1):36-44. doi: 10.1046/j.1365-2567.1999.00758.x. Immunology. 1999. PMID: 10447712 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous